Ukpo Grace E, Ebuehi O A T, Kareem A A
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, P. M. B 12003, Lagos, Nigeria.
Indian J Pharm Sci. 2012 Sep;74(5):454-7. doi: 10.4103/0250-474X.108422.
The aim of the present study was to investigate the toxicological effects of moxifloxacin in mice to determine the toxicological implications. Forty mice of both sexes were divided into four groups of 10 mice each, designated as A, B, C and D. Group A served as the control and received 2 ml of distilled water, while Groups B, C and D were orally administered 12.5, 25 and 50 mg/kg body weight of moxifloxacin once daily for 7 days, respectively. The weights of the mice were recorded before and throughout the duration of drug administration. Blood samples were collected for serum analysis. Total blood protein, cholesterol, triglyceride, creatinine, activities of aspartate transaminase, alanine transaminase and alkaline phosphatase, levels of high density lipoprotein-cholesterol and low density lipoprotein-cholesterol were assayed. There were significant (P≤0.05) differences in the concentrations of serum creatinine, urea, aspartate transaminase, alanine transaminase and alkaline phosphatase, levels of high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, cholesterol and triglyceride of mice administered moxifloxacin. Serum level of total bilirubin in low dose treated animals was not significantly different from that of the control group animals, but there were significant dose dependent decrease in the animals treated with 25 mg/kg as well as 50 mg/kg. Data of the study indicate there was a dose dependent reduction in the protein metabolites, lipid profile and liver enzyme activities of mice administered moxifloxacin.
本研究的目的是调查莫西沙星对小鼠的毒理学影响，以确定其毒理学意义。将40只雌雄小鼠分成四组，每组10只，分别命名为A、B、C和D组。A组作为对照组，给予2毫升蒸馏水，而B、C和D组分别每天口服12.5、25和50毫克/千克体重的莫西沙星，持续7天。在给药前及给药期间记录小鼠体重。采集血样进行血清分析。检测总血蛋白、胆固醇、甘油三酯、肌酐、天冬氨酸转氨酶、丙氨酸转氨酶和碱性磷酸酶的活性、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平。给予莫西沙星的小鼠血清肌酐、尿素、天冬氨酸转氨酶、丙氨酸转氨酶和碱性磷酸酶的浓度、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、胆固醇和甘油三酯水平存在显著（P≤0.05）差异。低剂量治疗动物的血清总胆红素水平与对照组动物无显著差异，但在给予25毫克/千克及50毫克/千克的动物中存在显著的剂量依赖性降低。研究数据表明，给予莫西沙星的小鼠的蛋白质代谢产物、血脂谱和肝酶活性存在剂量依赖性降低。
