Department of Pharmacology, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Hyderabad, Andhra Pradesh, India.
Indian J Pharmacol. 2013 Mar-Apr;45(2):155-8. doi: 10.4103/0253-7613.108299.
The objective was to study the of drug-drug interaction between voriconazole and oral hypoglycemic agents in normal and alloxan induced diabetic rats.
The study was designed in two phases. In the first phase, influence of glibenclamide (0.45 mg/kg, p.o.) and pioglitazone (2.7 mg/kg, p.o. once daily) on blood glucose levels in normoglycemic rats was studied and then influence of voriconazole (18 mg/kg, p.o. twice daily.) pre-treatment on the hypoglycemic activity studied. Simultaneously the influence of voriconazole treatment for seven consecutive days (per se effect) on blood glucose levels was also studied in normoglycemic rats. In the second phase of the study alloxan-induced diabetic rats were used to find out the influence of voriconazole pre-treatment on glibenclamide and pioglitazone induced hypoglycemic effect in pathophysiological condition. Blood samples were collected from retro orbital plexus at regular intervals of 0.0, 0.5, 1.0, 2.0, 4.0, 8.0, 12.0, 18.0 and 24.0 h after drug treatment. All the blood samples were analyzed for plasma glucose by glucose oxidase peroxidase method (GOD/POD).
The therapeutic dose of voriconazole potentiates the hypoglycemic activity of glibenclamide and pioglitazone both in normoglycemic and diabetic rats respectively.
The results indicate that the dose of oral hypoglycemic agents needs to be adjusted if co-administered with voriconazole.
研究伏立康唑与口服降糖药在正常和四氧嘧啶诱导的糖尿病大鼠中的药物相互作用。
该研究分为两个阶段。在第一阶段，研究了格列本脲（0.45mg/kg，po）和吡格列酮（2.7mg/kg，po，每日一次）对正常血糖大鼠血糖水平的影响，然后研究了伏立康唑（18mg/kg，po，每日两次）预处理对降血糖活性的影响。同时，还研究了连续 7 天给予伏立康唑（自身作用）对正常血糖大鼠血糖水平的影响。在研究的第二阶段，使用四氧嘧啶诱导的糖尿病大鼠，以发现伏立康唑预处理对格列本脲和吡格列酮在病理生理条件下引起的低血糖作用的影响。在药物治疗后 0.0、0.5、1.0、2.0、4.0、8.0、12.0、18.0 和 24.0 h 时，从眶后丛采集血样。所有血样均采用葡萄糖氧化酶过氧化物酶法（GOD/POD）分析血浆葡萄糖。
治疗剂量的伏立康唑增强了格列本脲和吡格列酮在正常血糖和糖尿病大鼠中的降血糖作用。
结果表明，如果与伏立康唑联合使用，口服降糖药的剂量需要调整。
