Patel Ankur G, Shah Avani P, Sorathiya Smita M, Gupte Snehalata C
Surat Raktadan Kendra and Research Centre, (NABH Accredited Regional Blood Transfusion Centre), Surat, Gujarat, India.
Indian J Hum Genet. 2012 Sep;18(3):294-8. doi: 10.4103/0971-6866.107979.
To Screen of South Gujarat population for determination of prevalence of different hemoglobinopathies particularly beta thalassemia trait (BTT) and sickle cell trait (SCT) and find out the incidence of anemia in them.
The present study screened 32,857 samples of students from different school and colleges in South Gujarat. Blood samples were initially tested for solubility test and complete hemogram on hematology analyzer. Samples having MCV (≤78), MCH (≤28) and/or positive solubility test were investigated for Hb electrophoresis on cellulose acetate membrane (pH 8.6). Hb A2 level ≥3.5% was considered as diagnostic for BTT. High performance liquid chromatography on Biorad Hb variant system was done on samples having doubtful results.
Overall prevalence of BTT and SCT in South Gujarat was 4.4% and 1.3% respectively. Gamit, Vasava, Chaudhary, and Mahyavanshi castes had high prevalence of BTT (15.9%, 13.6%, 12.6%, and 6.9%) as well as SCT (22.2%, 15.2, 22.3, and 4.2%) respectively. Other communities like Lohana (10.8%), Sindhi (10.2%), Prajapati (6.3%), and Ghanchi (6.2%) also showed higher prevalence of BTT. Incidence of mild to moderate anemia was higher in BTT and SCT compared to non-BTT or non-SCT subjects.
Study suggests that BTT is the most prevalent hemoglobinopathy in South Gujarat. β-thalassemia and Sickle cell anemia are highly prevalent in Mahyavanshi, Chaudhary, Gamit, Vasava and Rohit. Prajapati, Lohana, Leva Patel, and Ghanchi have β- thalassemia risk. SCT is more frequently detected in Dhodia Patel and Kukanas.
对古吉拉特邦南部人群进行筛查，以确定不同血红蛋白病的患病率，尤其是β地中海贫血特征（BTT）和镰状细胞特征（SCT），并找出其中贫血的发病率。
本研究对古吉拉特邦南部不同学校和学院的32857名学生样本进行了筛查。血液样本首先进行溶解度试验，并在血液分析仪上进行全血细胞计数。对平均红细胞体积（MCV）≤78、平均红细胞血红蛋白含量（MCH）≤28和/或溶解度试验呈阳性的样本，在醋酸纤维素膜（pH 8.6）上进行血红蛋白电泳检测。血红蛋白A2水平≥3.5%被视为BTT的诊断标准。对结果可疑的样本，采用Biorad血红蛋白变异系统进行高效液相色谱分析。
古吉拉特邦南部BTT和SCT的总体患病率分别为4.4%和1.3%。加米特、瓦萨瓦、乔杜里和马亚万希种姓的BTT患病率较高（分别为15.9%、13.6%、12.6%和6.9%），SCT患病率也较高（分别为22.2%、15.2%、22.3%和4.2%）。其他社区如洛哈纳（10.8%）、信德（10.2%）、普拉贾帕蒂（6.3%）和甘奇（6.2%）的BTT患病率也较高。与非BTT或非SCT受试者相比，BTT和SCT中轻度至中度贫血的发病率更高。
研究表明，BTT是古吉拉特邦南部最常见的血红蛋白病。β地中海贫血和镰状细胞贫血在马亚万希、乔杜里、加米特、瓦萨瓦和罗希特中高度流行。普拉贾帕蒂、洛哈纳、列瓦·帕特尔和甘奇有β地中海贫血风险。SCT在多迪亚·帕特尔和库卡纳斯中更常被检测到。
