Chatterjea J B
Bull World Health Organ. 1966;35(6):837-56.
The present world-wide interest in haemoglobinopathies and allied disorders has given rise to a very considerable literature over the past two decades. This communication reviews this literature in so far as it refers to the Indian subcontinent. The most common abnormality is thalassaemia, which has been discovered in all regions under consideration: India, Pakistan, Nepal, Bhutan and Ceylon. Haemoglobins S, D and E are also quite common: Hb S has been found mostly in the aboriginal tribes, Hb D in Gujaratis and Punjabis and Hb E in Bengalis, Assamese and Nepalese. A few instances of haemoglobins F, H, J, K, L and M have also been reported. However, there remain many population groups to be investigated.Studies of the distribution of glucose-6-phosphate dehydrogenase deficiency are also reviewed, and the correlation between the various haemoglobin disorders and various environmental factors is discussed, but it is pointed out that the relevant data are still insufficient to allow any definite conclusions to be drawn.
在过去二十年中，全球对血红蛋白病及相关疾病的关注引发了大量的文献。本通讯回顾了与印度次大陆相关的这方面文献。最常见的异常是地中海贫血，在所有涉及的地区都有发现：印度、巴基斯坦、尼泊尔、不丹和锡兰。血红蛋白S、D和E也相当常见：血红蛋白S主要在原住民部落中发现，血红蛋白D在古吉拉特人和旁遮普人中发现，血红蛋白E在孟加拉人、阿萨姆人和尼泊尔人中发现。也有一些血红蛋白F、H、J、K、L和M的病例报告。然而，仍有许多人群有待研究。本文还回顾了葡萄糖-6-磷酸脱氢酶缺乏症的分布研究，并讨论了各种血红蛋白疾病与各种环境因素之间的相关性，但指出相关数据仍不足以得出任何明确结论。
