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一例急性髓系白血病伴成熟患者中的一种新的11;18易位。

A novel 11;18 translocation in a case of acute myeloid leukemia with maturation.

作者信息

Sandhya Devi G, Ahmed Faiq, Khadke Kavita, Murthy Sudha S, Rajappa Senthil J

机构信息

Department of Laboratory Medicine, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India.

出版信息

Indian J Hum Genet. 2012 Sep;18(3):369-72. doi: 10.4103/0971-6866.108050.

DOI:10.4103/0971-6866.108050
PMID:23716952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3656533/
Abstract

Acute myeloid leukemia with maturation (AML-M2) is associated with the 8;21 translocation. For the first time in an adult patient with AML-M2, a novel unbalanced translocation involving the short arm of chromosome 11 and long arm of chromosome18 with new breakpoints is presented. CD82 on band 11p11.2 and GATA 6 on 18q11.2 may play a role in the pathogenesis of de novo AML M2. The report with translocation (11;18)(p11.2;q11.2), as the sole cytogenetic abnormality provides more data on the leukemogenesis of de novo AML M2.

摘要

伴成熟急性髓系白血病（AML-M2）与8;21易位相关。本文首次报道了一名成年AML-M2患者存在一种涉及11号染色体短臂和18号染色体长臂的新型不平衡易位，且具有新的断点。位于11p11.2带的CD82和18q11.2带的GATA 6可能在初发AML M2的发病机制中起作用。关于易位（11;18）（p11.2;q11.2）作为唯一细胞遗传学异常的报道为初发AML M2的白血病发生提供了更多数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c44e/3656533/99f8e40f315c/IJHG-18-369-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c44e/3656533/89a201942bcc/IJHG-18-369-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c44e/3656533/b0b2a219a4ab/IJHG-18-369-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c44e/3656533/822be7aebf9c/IJHG-18-369-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c44e/3656533/99f8e40f315c/IJHG-18-369-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c44e/3656533/89a201942bcc/IJHG-18-369-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c44e/3656533/b0b2a219a4ab/IJHG-18-369-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c44e/3656533/822be7aebf9c/IJHG-18-369-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c44e/3656533/99f8e40f315c/IJHG-18-369-g004.jpg

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引用本文的文献

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本文引用的文献

1
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes.世界卫生组织（WHO）髓系肿瘤和急性白血病分类的2008年修订版：基本原理及重要变化
Blood. 2009 Jul 30;114(5):937-51. doi: 10.1182/blood-2009-03-209262. Epub 2009 Apr 8.
2
Clinical significance of the most common chromosome translocations in adult acute myeloid leukemia.成人急性髓系白血病中最常见染色体易位的临床意义
J Natl Cancer Inst Monogr. 2008(39):52-7. doi: 10.1093/jncimonographs/lgn003.
3
The 8;21 translocation in leukemogenesis.
白血病发生中的8号与21号染色体易位
Oncogene. 2004 May 24;23(24):4255-62. doi: 10.1038/sj.onc.1207727.