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皮肤黑色素瘤中转化生长因子-β信号通路的见解

Insights into the Transforming Growth Factor-β Signaling Pathway in Cutaneous Melanoma.

作者信息

Perrot Carole Yolande, Javelaud Delphine, Mauviel Alain

机构信息

Institut Curie, Team "TGF-β and Oncogenesis", Equipe Labellisée Ligue Contre le Cancer, Orsay, France. ; INSERM U1021 Orsay, France. ; CNRS UMR 3347, Orsay, France.

出版信息

Ann Dermatol. 2013 May;25(2):135-44. doi: 10.5021/ad.2013.25.2.135.

DOI:10.5021/ad.2013.25.2.135
PMID:23717002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3662904/
Abstract

Transforming growth factor-β (TGF-β) is a pleiotropic growth factor with broad tissue distribution that plays critical roles during embryonic development, normal tissue homeostasis, and cancer. While its cytostatic activity on normal epithelial cells initially defined TGF-β signaling as a tumor suppressor pathway, there is ample evidence indicating that TGF-β is a potent pro-tumorigenic agent, acting via autocrine and paracrine mechanisms to promote peri-tumoral angiogenesis, together with tumor cell migration, immune escape, and dissemination to metastatic sites. This review summarizes the current knowledge on the implication of TGF-β signaling in melanoma.

摘要

转化生长因子-β（TGF-β）是一种多效性生长因子，广泛分布于组织中，在胚胎发育、正常组织稳态和癌症过程中发挥关键作用。虽然其对正常上皮细胞的细胞抑制活性最初将TGF-β信号传导定义为一种肿瘤抑制途径，但有充分证据表明，TGF-β是一种强大的促肿瘤发生因子，通过自分泌和旁分泌机制发挥作用，促进肿瘤周围血管生成，以及肿瘤细胞迁移、免疫逃逸和向转移部位扩散。本综述总结了目前关于TGF-β信号传导在黑色素瘤中的作用的知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12af/3662904/f157fd4564e1/ad-25-135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12af/3662904/57b6b66ad14d/ad-25-135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12af/3662904/f157fd4564e1/ad-25-135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12af/3662904/57b6b66ad14d/ad-25-135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12af/3662904/f157fd4564e1/ad-25-135-g002.jpg

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TGF-β signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells.
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