Jo Seong Jin, Shin Hyoseung, Paik Seung Hwan, Na Sun Jae, Jin Yingji, Park Won Seok, Kim Su Na, Kwon Oh Sang
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
Ann Dermatol. 2013 May;25(2):218-22. doi: 10.5021/ad.2013.25.2.218. Epub 2013 May 10.
Graying of hair-a sign of aging-raises cosmetic concerns. Individuals with gray hair often look older than others their age; therefore, some dye their hair for aesthetic purposes. However, hair colorants can induce many problems including skin irritation, allergic reaction and hair-breakage.
This randomized, double-blind clinical trial was performed in order to examine the effects of APHG-1001, a compound including an extract from Pueraria lobata, on graying hair.
A total of 44 female subjects were randomly treated with either APHG-1001 or placebo twice daily for 24 weeks. Using the phototrichogram analysis, a count of newly developed gray hair was estimated. Investigator assessment and subject self-assessment were also performed in order to evaluate the efficacy of the compound.
The mean number of newly developed gray hair at 24 weeks was 6.3/cm(2) in the APHG-1001 group and 11.4/cm(2) in the placebo group; the difference was statistically significant (p<0.05). However, the investigator assessment and subject self-assessment did not show any significant change in the gross appearance of hair grayness by the end of the study. No severe adverse events in either group were observed. Moreover, the incidence of adverse events did not differ between the groups.
This clinical trial revealed that APHG-1001, which contains an extract of P. lobata, could prevent the development of new gray hair without any remarkable adverse effects. Thus, it can be considered as a viable treatment option for the prevention of gray hair.
头发变白——衰老的一种表现——引发了人们对美容的关注。白发人群往往看起来比同龄人更显老；因此，一些人为了美观而染发。然而，染发剂会引发诸多问题，包括皮肤刺激、过敏反应和头发断裂。
开展这项随机、双盲临床试验，以研究包含野葛提取物的化合物APHG - 1001对白发的影响。
总共44名女性受试者被随机分为两组，一组每日两次接受APHG - 1001治疗，另一组接受安慰剂治疗，为期24周。通过毛发照相分析估计新出现白发的数量。还进行了研究者评估和受试者自我评估，以评价该化合物的疗效。
24周时，APHG - 1001组新出现白发的平均数量为6.3根/平方厘米，安慰剂组为11.4根/平方厘米；差异具有统计学意义（p<0.05）。然而，在研究结束时，研究者评估和受试者自我评估均未显示头发灰度总体外观有任何显著变化。两组均未观察到严重不良事件。此外，两组不良事件的发生率无差异。
这项临床试验表明，含有野葛提取物的APHG - 1001可预防新白发的出现，且无明显不良反应。因此，它可被视为预防白发的一种可行治疗选择。
