Tamgadge Sandhya, Tamgadge Avinash, Modak Neha, Bhalerao Sudhir
Department of Oral & Maxillofacial Pathology and Microbiology, Padmashree Dr DY Patil Dental College & Hospital, Sector 7, Nerul, Navi Mumbai, Maharashtra, Pin-400706, India.
Ecancermedicalscience. 2013 May 9;7:316. doi: 10.3332/ecancer.2013.316. Print 2013.
Primary intraosseous squamous cell carcinoma (PIOSCC) derived from an odontogenic keratocyst (OKC) is a rare malignant neoplasm of the jaws, which is locally aggressive with quite poor prognosis. The incidence of carcinomas arising in odontogenic cysts was reported to be approximately 1-2/1000. The number of well-documented cases of PIOSCC ex OKC is extremely small; hence, no sufficient incidence data are available in the literature. Overall, the survival rate of an individual, which is a period of two years, is very poor, and this can be attributed to the delayed diagnosis. But knowledge of the histopathological and immunohistological features of PIOSCC allows accurate and early diagnosis of the lesion so that an early and appropriate treatment can be instituted for better prognosis. The following report describes an extremely rare case of PIOSCC of the mandible derived from an OKC in a 20-year-old female patient.
源自牙源性角化囊肿（OKC）的原发性骨内鳞状细胞癌（PIOSCC）是一种罕见的颌骨恶性肿瘤，具有局部侵袭性且预后很差。据报道，牙源性囊肿发生癌变的发生率约为1-2/1000。有充分文献记载的源自OKC的PIOSCC病例数量极少；因此，文献中没有足够的发病率数据。总体而言，个体的两年生存率非常低，这可归因于诊断延迟。但是，了解PIOSCC的组织病理学和免疫组织学特征有助于准确早期诊断病变，从而能够采取早期适当治疗以获得更好的预后。以下报告描述了一名20岁女性患者中源自OKC的下颌骨PIOSCC的极其罕见病例。
