Department of Oral and Maxillofacial Surgery, Soroka University Medical Center and Ben-Gurion University of the Negev, Beer-Sheva, Israel.
J Oral Pathol Med. 2011 Nov;40(10):733-8. doi: 10.1111/j.1600-0714.2011.01058.x. Epub 2011 Jun 21.
To review the literature on primary intraosseous squamous cell carcinoma (PIOSCC) associated with odontogenic cyst.
All well-documented cases of PIOSCC published between 1938 and 2010 were collected. Only cases of PIOSCC arising from the lining of an odontogenic cyst, including the keratocystic odontogenic tumor, were selected. Age, sex, signs and symptoms, affected jaw, cyst type, treatment, histopathology, and outcome were recorded.
The mean age was 60.2 years (range 1.3-90). There were 80 (69%) men and 36 (31%) women. Mass and pain were the most common presenting symptoms. The mandible was affected in 92 (79%) patients and the maxilla in 24 (21%). It was a residual/radicular cyst in 70 (60%) patients and a dentigerous cyst or a keratocystic odontogenic tumor in the remaining 40%. The histopathology was well-differentiated SCC in 53 (46%) patients and moderately differentiated SCC in 47 (40%) patients. Fifty-three (46%) patients were treated with surgery alone and 44 (38%) with surgery and radiotherapy. Fifty-eight (62%) patients survived 2 years and 36 (38%) survived 5 years.
PIOSCC has a predilection for men (M/F ratio of 2.22:1), affects mainly adults in their 6-8th decades, occurs most frequently (79%) in the mandible, and is associated mainly with a residual/radicular cyst. Histologically, the well-to-moderately differentiated SCC was the most common. Surgery alone or combined therapy of surgery and radiation was the most common approach. The prognosis is 62% surviving 2 years and 38% 5 years.
回顾原发性骨内鳞状细胞癌（PIOSCC）与牙源性囊肿相关的文献。
收集了 1938 年至 2010 年间发表的所有有充分记录的 PIOSCC 病例。仅选择了源自牙源性囊肿衬里的 PIOSCC 病例，包括角化囊肿性牙源性肿瘤。记录了年龄、性别、体征和症状、受累颌骨、囊肿类型、治疗、组织病理学和结果。
平均年龄为 60.2 岁（范围 1.3-90）。男性 80 例（69%），女性 36 例（31%）。肿块和疼痛是最常见的症状。下颌受累 92 例（79%），上颌受累 24 例（21%）。其中 70 例（60%）为残余/根囊肿，40 例（40%）为含牙囊肿或角化囊肿性牙源性肿瘤。组织病理学表现为分化良好的 SCC 53 例（46%），中分化 SCC 47 例（40%）。53 例（46%）患者仅接受手术治疗，44 例（38%）患者接受手术和放疗。58 例（62%）患者 2 年生存率为 62%，36 例（38%）患者 5 年生存率为 38%。
PIOSCC 男性患病率较高（男女比例为 2.22:1），主要影响 6-8 十年代的成年人，最常发生于下颌骨（79%），主要与残余/根囊肿相关。组织学上，最常见的是中高度分化的 SCC。单独手术或手术联合放疗是最常见的治疗方法。2 年生存率为 62%，5 年生存率为 38%。
