Veit M, Herrler G, Schmidt M F, Rott R, Klenk H D
Institut für Virologie, Philipps-Universität Marburg, Federal Republic of Germany.
Virology. 1990 Aug;177(2):807-11. doi: 10.1016/0042-6822(90)90554-5.
We present evidence that the hemagglutinin (HA) of influenza B virus and the glycoprotein of influenza C virus (HEF) are acylated. The fatty acid linkage is sensitive to treatment with hydroxylamine and mercaptoethanol, which points to a labile thioester-type linkage. The HA of influenza B virus contains mainly palmitic acid, whereas the HEF glycoprotein of influenza C virus is acylated with stearic acid which has not been observed before as the prevailing fatty acid in viral or cellular acyl proteins.
我们提供的证据表明，乙型流感病毒的血凝素（HA）和丙型流感病毒的糖蛋白（HEF）是被酰化的。脂肪酸连接对羟胺和巯基乙醇处理敏感，这表明存在不稳定的硫酯型连接。乙型流感病毒的HA主要含有棕榈酸，而丙型流感病毒的HEF糖蛋白则被硬脂酸酰化，硬脂酸作为病毒或细胞酰基蛋白中的主要脂肪酸此前尚未被观察到。
