Department of Chemical Engineering, North Tehran Branch, Islamic Azad University, Tehran, Iran.
J Nanobiotechnology. 2013 May 29;11:16. doi: 10.1186/1477-3155-11-16.
Nanocapsules have many applications in the drug, cosmetic, fragrance, and food industries. In this study, Crataegus azarolus L. nanocapsules were prepared by a modified emulsion diffusion technique.
In this technique a shell was first made from the polyester triblock copolymer poly(ethylene glycol)-poly(butylene adipate)-poly(ethylene glycol) (PEG-PBA-PEG) and then olive oil was set as the core of the nanocapsule by a method known as the polymer deposition solvent evaporation method. Varying amounts of C. azarolus extract, polymer, and olive oil were mixed in acetone and then added to water on a shaker. Finally, the acetone was removed by vacuuming.
The size of the prepared nanocapsules were measured with a particle size analysis report (PSAR) and identified by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and nuclear magnetic resonance (NMR).
Our experiments showed that the size of the nanocapsules depends on the preparation conditions, i.e., the ratio of polymer to oil and concentrations of polymer and plant extract. A ratio of 1:0.25 polymer to oil was shown to be more suitable for the formation of smaller nanocapsules of C. azarolus.
纳米胶囊在药物、化妆品、香料和食品等行业有广泛的应用。在本研究中，采用改良的乳化扩散技术制备了山楂纳米胶囊。
在该技术中，首先由聚酯三嵌段共聚物聚（乙二醇）-聚（丁二酸丁二醇酯）-聚（乙二醇）（PEG-PBA-PEG）制成壳，然后通过聚合物沉积溶剂蒸发法将橄榄油设置为纳米胶囊的核。将不同量的山楂提取物、聚合物和橄榄油混合在丙酮中，然后在振荡器上加入水中。最后，通过真空去除丙酮。
用粒度分析报告（PSAR）测量所制备的纳米胶囊的大小，并通过扫描电子显微镜（SEM）、傅里叶变换红外光谱（FTIR）和核磁共振（NMR）进行鉴定。
我们的实验表明，纳米胶囊的大小取决于制备条件，即聚合物与油的比例以及聚合物和植物提取物的浓度。实验表明，聚合物与油的比例为 1:0.25 更有利于形成更小的山楂纳米胶囊。
