Takita Masatoshi, Fujiwara Sei-Etsu, Izaki Yoshinori
Cognition and Action Research Group, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan; Department of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Japan.
J Physiol Paris. 2013 Dec;107(6):441-7. doi: 10.1016/j.jphysparis.2013.05.002. Epub 2013 May 26.
The hippocampo-prefrontal pathway is a unique projection that connects distant ends of the cerebral cortex. The direct hippocampo-prefrontal projection arises from the ventral to intermediate third of the hippocampus, but not from the dorsal third. It forms a funnel-shaped structure that collects information from the large hippocampal area and projects it to the prefrontal cortex. The anatomical regional differentiation of the projection has not been described. The hippocampal region is differentiated into structural and behavioural roles. For example, it has been shown that the ventral, but not the dorsal, hippocampus reciprocally connects with the amygdala and influences emotional behaviours. These data imply that hippocampal variation along the dorso-ventral axis is contained within the hippocampo-prefrontal pathway. Here, we present electrophysiological studies that demonstrate regional differences in short- but not long-term plasticity in the intermediate/posterior-dorsal and ventral routes of the hippocampo-prefrontal pathway. Furthermore, behavioural studies revealed that each route appears to play a different role in working memory. These results suggest that hippocampal regional information is processed through different routes, with the integration of individual regulatory functions in the prefrontal convergent system.
海马体-前额叶通路是一种独特的投射，连接大脑皮层的远端。直接的海马体-前额叶投射起源于海马体腹侧至中间三分之一处，而非背侧三分之一处。它形成一个漏斗状结构，从大面积的海马体区域收集信息并投射到前额叶皮层。该投射的解剖区域分化尚未被描述。海马体区域在结构和行为方面具有不同作用。例如，研究表明腹侧海马体而非背侧海马体与杏仁核相互连接并影响情绪行为。这些数据表明，海马体沿背腹轴的差异存在于海马体-前额叶通路中。在此，我们展示了电生理研究结果，这些结果表明海马体-前额叶通路的中间/后背部和腹侧路径在短期而非长期可塑性方面存在区域差异。此外，行为学研究表明，每条路径在工作记忆中似乎发挥着不同作用。这些结果表明，海马体区域信息通过不同路径进行处理，个体调节功能在前额叶汇聚系统中得以整合。
