男男性行为的HIV感染者的体重指数、免疫状态和病毒学控制情况
Body mass index, immune status, and virological control in HIV-infected men who have sex with men.
作者信息
Blashill Aaron J, Mayer Kenneth H, Crane Heidi M, Grasso Chris, Safren Steven A
机构信息
Harvard Medical School, Boston, MA, USA.
出版信息
J Int Assoc Provid AIDS Care. 2013 Sep-Oct;12(5):319-24. doi: 10.1177/2325957413488182. Epub 2013 May 29.
Abstract
BACKGROUND AND AIMS
Prior cross-sectional studies have found inconsistent relationships between body mass index (BMI) and disease progression in HIV-infected individuals.
METHODS
Cross-sectional and longitudinal analyses were conducted on data from a sample of 864 HIV-infected men who have sex with men (MSM) obtained from a large, nationally distributed HIV clinical cohort.
RESULTS
Of the 864 HIV-infected MSM, 394 (46%) were of normal weight, 363 (42%) were overweight, and 107 (12%) were obese at baseline. The baseline CD4 count was 493 (standard error [SE] = 9), with viral load (log10) = 2.4 (SE = .04), and 561 (65%) were virologically suppressed. Over time, controlling for viral load, highly active antiretroviral therapy (HAART) adherence, age, and race/ethnicity, overweight and obese HIV-infected men possessed higher CD4 counts than that of normal weight HIV-infected men. Further, overweight and obese men possessed lower viral loads than that of normal weight HIV-infected men.
CONCLUSIONS
For HIV-infected MSM, in this longitudinal cohort study, possessing a heavier than normal BMI is longitudinally associated with improved immunological health.
摘要
背景与目的
既往横断面研究发现，体重指数（BMI）与HIV感染者疾病进展之间的关系并不一致。
方法
对来自一个大型全国性HIV临床队列的864名男男性行为者（MSM）HIV感染者样本的数据进行横断面和纵向分析。
结果
在864名HIV感染的男男性行为者中，394人（46%）基线体重正常，363人（42%）超重，107人（12%）肥胖。基线CD4细胞计数为493（标准误[SE]=9），病毒载量（log10）=2.4（SE=0.04），561人（65%）病毒学抑制。随着时间推移，在控制病毒载量、高效抗逆转录病毒治疗（HAART）依从性、年龄和种族/民族的情况下，超重和肥胖的HIV感染男性的CD4细胞计数高于体重正常的HIV感染男性。此外，超重和肥胖男性的病毒载量低于体重正常的HIV感染男性。
结论
在这项纵向队列研究中，对于HIV感染的男男性行为者，BMI高于正常水平与免疫健康改善在纵向层面相关。
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