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早产儿视网膜病变与氧的难题:近期随机试验得到的经验教训。

Retinopathy of prematurity and the oxygen conundrum: lessons learned from recent randomized trials.

机构信息

Department of Ophthalmology, Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh, EH3 9HA, UK.

出版信息

Clin Perinatol. 2013 Jun;40(2):229-40. doi: 10.1016/j.clp.2013.02.010.

DOI:10.1016/j.clp.2013.02.010
PMID:23719307
Abstract

Emerging data from randomised controlled trials of different pulse oximeter oxygen saturation (SpO(2)) target ranges shows that higher SpO(2) targets are associated with a higher risk of severe retinopathy of prematurity. However, the trials have also shown that higher SpO(2) targets are associated with improved survival. In the light of these results and pending the full results for long-term outcome, it is recommended that oxygen saturation targets for preterm infants of gestational age less than 28 weeks at birth should be maintained at or more than 90%.

摘要

新兴的随机对照试验数据表明,不同脉氧仪氧饱和度(SpO2)目标范围与早产儿重度视网膜病变的风险增加相关。然而,这些试验也表明,较高的 SpO2 目标与存活率提高相关。鉴于这些结果,在等待长期结果的情况下,建议将胎龄小于 28 周的早产儿的氧饱和度目标维持在 90%或以上。

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Retinopathy of prematurity and the oxygen conundrum: lessons learned from recent randomized trials.早产儿视网膜病变与氧的难题:近期随机试验得到的经验教训。
Clin Perinatol. 2013 Jun;40(2):229-40. doi: 10.1016/j.clp.2013.02.010.
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High or low oxygen saturation for the preterm baby.早产儿的高氧或低氧饱和度
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High or low oxygen saturation for the preterm baby.早产儿的高氧或低氧饱和度
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Study protocol: safety and efficacy of propranolol 0.2% eye drops in newborns with a precocious stage of retinopathy of prematurity (DROP-ROP-0.2%): a multicenter, open-label, single arm, phase II trial.研究方案:0.2%普萘洛尔滴眼液用于早产视网膜病变早熟期新生儿的安全性和有效性(DROP-ROP-0.2%):一项多中心、开放标签、单臂、II期试验。
BMC Pediatr. 2017 Jul 14;17(1):165. doi: 10.1186/s12887-017-0923-8.
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Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity.用于预防和治疗早产儿视网膜病变的药物干预措施。
Semin Perinatol. 2016 Apr;40(3):189-202. doi: 10.1053/j.semperi.2015.12.006. Epub 2016 Jan 29.
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The effect of oxygen saturation targeting on retinal blood vessel growth using retinal image data from the BOOST-II UK Trial.利用英国BOOST-II试验的视网膜图像数据研究氧饱和度目标对视网膜血管生长的影响。
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