[Genetic impairments of Wnt signaling pathways in hereditary high bone mass syndrome and sclerostosis diseases].

Investigations of hereditary skeletal diseases, such as high bone mass syndrome and sclerostosis diseases, have opened the door to understand molecular mechanisms for bone formation. Signal transduction activated by Wnt-Frizzled has been established to be critically and physiologically involved in the stimulation of bone formation by osteoblasts. LRP5, a co-receptor that binds Wnt to activate signal transduction through Frizzled, and sclerostin, an inhibitor of Wnt, are both indispensable molecules that stimulate and inhibit bone formation, respectively in health and diseases. Those are emerging target molecules to develop novel therapeutic drugs for osteoporosis.