Kubota Takuo, Ozono Keiichi
Department of Pediatrics, Osaka University Graduate School of Dentistry, Japan.
Clin Calcium. 2013 Jun;23(6):855-60.
Wnt signaling pathway components have been shown to be involved in bone biology since mutations in the LRP5 gene proved to cause osteoporosis-pseudoglioma syndrome and high bone mass trait. Genome wide association studies have indicated that single nucleotide polymorphisms of various components in Wnt signaling pathways are associated with bone mineral density and risk for low-trauma fracture. Mouse genetic studies have demonstrated that multiple components in Wnt signaling pathways play significant roles in skeletal development and bone mass maintenance. Here we review several components in Wnt signaling pathways with their association with bone mineral density in humans.
自LRP5基因突变被证明可导致骨质疏松-假性神经胶质瘤综合征和高骨量性状以来，Wnt信号通路成分已被证明参与骨骼生物学过程。全基因组关联研究表明，Wnt信号通路中各种成分的单核苷酸多态性与骨密度和低创伤骨折风险相关。小鼠遗传学研究表明，Wnt信号通路中的多个成分在骨骼发育和骨量维持中起重要作用。在此，我们综述Wnt信号通路中的几个成分及其与人类骨密度的关联。
