Gottfried M R, Washington K, Harrell L J
Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Am J Gastroenterol. 1990 Jul;85(7):813-8.
To determine the prevalence and histology of Helicobacter pylori (HP) associated gastritis in young ferrets, we examined 36 normal 2- to 4-month old ferrets. Identification of HP-like microorganisms included Warthin Starry stains of tissue sections, rapid urease test on fresh tissue, and culture. HP-like microorganisms were found in the stomachs of 35/36 ferrets. The highest density of microorganisms was seen in the antrum, where HP-like microorganisms were present in the pits and in deep glands. HP-like microorganisms were also seen in the cardia and on the foveolar epithelium of the fundus, but not in fundic glands. Chronic active gastritis was seen in all animals with HP-like microorganisms, but involved only the antrum. The distal antrum was most severely involved. One animal had no evidence of HP-like microorganisms on tissue sections or by rapid urease test. Gastric tissue sections from this animal showed only minimal infiltration of the lamina propria by polymorphonuclear leukocytes and lymphocytes. Gastritis associated with HP-like microorganisms is common in ferrets and is acquired at a young age. It is associated with chronic active antral gastritis similar to that seen in humans, suggesting that ferrets should provide a useful experimental model for HP-associated gastritis and peptic ulcer.
为了确定幼龄雪貂幽门螺杆菌（HP）相关性胃炎的患病率和组织学特征，我们检查了36只2至4月龄的正常雪貂。HP样微生物的鉴定包括组织切片的沃辛-斯塔瑞染色、新鲜组织的快速尿素酶试验以及培养。在36只雪貂中的35只胃中发现了HP样微生物。微生物密度最高的部位是胃窦，在胃小凹和深部腺体中存在HP样微生物。在贲门和胃底的小凹上皮也可见HP样微生物，但在胃底腺中未见。所有有HP样微生物的动物均出现慢性活动性胃炎，但仅累及胃窦。胃窦远端受累最严重。一只动物在组织切片或快速尿素酶试验中未发现HP样微生物的证据。该动物的胃组织切片显示固有层仅有少量多形核白细胞和淋巴细胞浸润。与HP样微生物相关的胃炎在雪貂中很常见，且在幼年时获得。它与人类所见的慢性活动性胃窦炎相关，这表明雪貂应为HP相关性胃炎和消化性溃疡提供一个有用的实验模型。
