Brazer S R, Tyor M P, Pancotto F S, Nickl N J, Wildermann N M, Harrell F E, Pryor D B
Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Am J Gastroenterol. 1990 Jul;85(7):824-8.
A community-based group of gastroenterologists examined 623 patients (541 prospectively and 82 retrospectively) with endoscopically diagnosed gastric ulcer disease during a 12-month period. Patients averaged 60 years of age; the majority were women (62%). Women were less likely to smoke, abuse alcohol, and were more likely to present with abdominal pain (p less than 0.05). Whereas patients presenting with bleeding or requiring transfusion were less likely to complain of pain (p less than 0.05), they were more likely to be taking aspirin or nonsteroidal anti-inflammatory drugs and have prior history of bleeding (p less than 0.05). Patients with a prior history of ulcer disease were more likely to smoke, present with pain and use acetaminophen (p less than 0.05). Patients with large ulcers were more likely to bleed, present with pain, and obstruct (p less than 0.05). Multiple gastric ulcers were seen in patients taking aspirin or nonsteroidal anti-inflammatory drugs (p less than 0.05).
一个以社区为基础的胃肠病学家小组在12个月期间对623例经内镜诊断为胃溃疡疾病的患者进行了检查（541例为前瞻性研究，82例为回顾性研究）。患者平均年龄为60岁；大多数为女性（62%）。女性吸烟、酗酒的可能性较小，出现腹痛的可能性较大（p<0.05）。而出现出血或需要输血的患者抱怨疼痛的可能性较小（p<0.05），但他们服用阿司匹林或非甾体抗炎药的可能性较大，且有出血史（p<0.05）。有溃疡病史的患者吸烟、出现疼痛和使用对乙酰氨基酚的可能性较大（p<0.05）。溃疡较大的患者出血、出现疼痛和梗阻的可能性较大（p<0.05）。服用阿司匹林或非甾体抗炎药的患者出现多发性胃溃疡（p<0.05）。
