Skinner Heath D, Sturgis Erich M, Klopp Ann H, Ang Kie-Kian, Rosenthal David I, Garden Adam S, Morrison William H, Gunn G Brandon, Beadle Beth M
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Head Neck. 2014 Jun;36(6):819-25. doi: 10.1002/hed.23379. Epub 2013 Sep 2.
Human papillomavirus (HPV) is a causative factor in squamous cell carcinomas of the anus, penis, vagina, vulva, and head and neck, and adenocarcinoma of the cervix. We examined the demographics, clinical characteristics, and timing of multiple potentially HPV-related cancers in individual patients.
One hundred forty-three patients were identified with 300 potentially HPV-related cancers. The median follow-up from index and second cancer was 18.5 years and 3.2 years, respectively.
Median age at index and second cancer was 45 and 60.5 years of age, respectively, with a median interval of 11 years. Cervical cancer was the most common initial diagnosis (61.7%), whereas head and neck squamous cell carcinoma (HNSCC) was the most common second cancer (57.6%).
These data suggest differential patterns for development of multiple HPV-related cancers based upon clinical characteristics. Prospective longitudinal and population-based studies are warranted to understand the impact of these findings and opportunities for intervention and screening.
人乳头瘤病毒（HPV）是导致肛门、阴茎、阴道、外阴和头颈鳞状细胞癌以及子宫颈腺癌的一个致病因素。我们研究了个体患者中多种潜在HPV相关癌症的人口统计学特征、临床特征及发病时间。
确定了143例患有300种潜在HPV相关癌症的患者。首次癌症和第二次癌症的中位随访时间分别为18.5年和3.2年。
首次癌症和第二次癌症的中位年龄分别为45岁和60.5岁，中位间隔时间为11年。宫颈癌是最常见的初始诊断癌症（61.7%），而头颈鳞状细胞癌（HNSCC）是最常见的第二次癌症（57.6%）。
这些数据表明，基于临床特征，多种HPV相关癌症的发生模式存在差异。有必要开展前瞻性纵向研究和基于人群的研究，以了解这些发现的影响以及干预和筛查的机会。
