Nasr Ahmed, Langer Jacob C
Department of Surgery, University of Ottawa, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Eur J Pediatr Surg. 2013 Jun;23(3):191-7. doi: 10.1055/s-0033-1347916. Epub 2013 May 29.
Long-gap esophageal atresia (EA) represents a challenging problem for pediatric surgeons, and a large number of techniques and approaches have been proposed. One of the more recent, initially published by Foker, is the use of mechanical traction to accelerate the growth of the esophageal ends and permit earlier primary anastomosis. The purpose of this study is to critically evaluate the existing literature on this topic and to compare the Foker technique to the more conventional delayed primary anastomosis.
A systematic review and cumulative meta-analysis was performed, including all articles describing the Foker technique or delayed primary anastomosis. Primary outcome was complications, and secondary outcome was time to final anastomosis.
Six articles on the Foker procedure met the criteria for inclusion. None were prospective or randomized. These articles represented 71 infants undergoing the Foker procedure, which were compared with 451 children from 44 studies utilizing delayed primary anastomosis. The Foker procedure was associated with a significantly lower risk of complications (leak, stricture, and gastroesophageal reflux), and with a significantly shorter time to definitive anastomosis.
The use of mechanical traction appears to be at least as effective as delayed primary anastomosis for the management of long-gap EA. Future prospective studies and the establishment of a prospective registry are required to further elucidate this issue.
长段食管闭锁(EA)对小儿外科医生来说是一个具有挑战性的问题,人们已经提出了大量的技术和方法。福克最初发表的最新技术之一是使用机械牵引来加速食管两端的生长,并允许更早地进行一期吻合。本研究的目的是严格评估关于该主题的现有文献,并将福克技术与更传统的延迟一期吻合术进行比较。
进行了一项系统评价和累积荟萃分析,纳入了所有描述福克技术或延迟一期吻合术的文章。主要结局是并发症,次要结局是最终吻合的时间。
6篇关于福克手术的文章符合纳入标准。均非前瞻性或随机研究。这些文章代表了71例接受福克手术的婴儿,并与44项使用延迟一期吻合术的研究中的451名儿童进行了比较。福克手术的并发症(渗漏、狭窄和胃食管反流)风险显著较低,最终吻合的时间也显著较短。
对于长段食管闭锁的治疗,使用机械牵引似乎至少与延迟一期吻合术一样有效。需要未来的前瞻性研究和建立前瞻性登记系统来进一步阐明这个问题。