Ch'ng Sydney, Oates Justine, Gao Kan, Foo Kerwyn, Davies Sarah, Brunner Markus, Clark Jonathan R
Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Head Neck. 2014 Jun;36(6):834-40. doi: 10.1002/hed.23387. Epub 2013 Sep 2.
Postoperative radiation therapy (PORT) is frequently recommended to improve survival outcome. The effect of PORT-associated morbidity on patients' quality of life (QOL) is, however, not well established. This study assessed the effect of PORT on medium-term (ie, at 6 months) QOL in patients with oral cavity squamous cell carcinoma (SCC).
Patients completed the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and Quality of Life Questionnaire Core Head and Neck 35 (QLQ-HN35) at initial presentation, and at 3-, 6-, and 12-month follow-up. Baseline QOL scores were adjusted for using analysis of covariance (ANCOVA).
Global health status (mean difference = 13.3; p = .042) and xerostomia (mean difference = 35.4; p = .003) were significantly worse at 6 months in patients who received PORT compared to those treated with surgery alone.
The survival advantage needs to be balanced against increased treatment toxicity. PORT is associated with reduced global health status, increased xerostomia, and marginally increased levels of fatigue at 6 months posttreatment for oral cavity cancer.
术后放射治疗（PORT）常被推荐用于改善生存结局。然而，PORT相关的发病率对患者生活质量（QOL）的影响尚未明确。本研究评估了PORT对口腔鳞状细胞癌（SCC）患者中期（即6个月时）生活质量的影响。
患者在初次就诊时以及3个月、6个月和12个月随访时完成欧洲癌症研究与治疗组织生活质量问卷核心30（EORTC QLQ-C30）和生活质量问卷核心头颈部35（QLQ-HN35）。使用协方差分析（ANCOVA）对基线生活质量评分进行调整。
与单纯接受手术治疗的患者相比，接受PORT治疗的患者在6个月时的总体健康状况（平均差异=13.3；p=0.042）和口干（平均差异=35.4；p=0.003）明显更差。
生存优势需要与增加的治疗毒性相平衡。PORT与口腔癌治疗后6个月时总体健康状况下降、口干增加以及疲劳水平略有增加有关。
