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[他汀类药物治疗与认知]

[Statin therapy and cognition].

作者信息

Strandberg Timo, Strandberg Arto

机构信息

Helsingen yliopisto, HYKS.

出版信息

Duodecim. 2013;129(7):713-8.

Abstract

Cognitive problems caused by statins have been noted above all in individual patient cases and to some extent also in epidemiological surveys. The connection may also arise from the fact that by lowering cardiovascular disease mortality statins may predispose their users to the development of memory disorders at an older age. In randomized studies statins have generally been found to have neither adverse nor clearly positive effects on cognition. While the effect of statins on cognition can be evaluated as being neutral, the symptoms complained by the patient must always be considered on a case-by-case basis.

摘要

他汀类药物引起的认知问题首先在个别患者病例中被注意到,在一定程度上也在流行病学调查中有所发现。这种关联也可能源于这样一个事实,即通过降低心血管疾病死亡率,他汀类药物可能使使用者在老年时更容易出现记忆障碍。在随机研究中,一般发现他汀类药物对认知既无不良影响也无明显积极影响。虽然他汀类药物对认知的影响可被评估为中性,但必须始终根据具体情况考虑患者所抱怨的症状。

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