Department of Traumatology and Emergency Surgery, Chang-Gung memorial hospital, Linkou Fu-Shin Street, Taoyuan 333, Taiwan.
World J Surg Oncol. 2013 May 31;11:124. doi: 10.1186/1477-7819-11-124.
Adenosquamous carcinoma is defined as a tumor in which both glandular and squamous elements are histologically malignant. Although some published studies have analyzed and discussed adenosquamous carcinomas, hybrid malignancy of the ampulla of Vater has rarely been discussed thus far in the literature. In this study, we report the case of a 64-year-old man who presented with jaundice and intermittent abdominal dull pain that persisted for several weeks. The patient was diagnosed with adenosquamous carcinoma of the ampulla of Vater and underwent pancreaticoduodenectomy. The final diagnosis was adenosquamous carcinoma of the ampulla of Vater, T3N1M0, stage IIB. Although R0 resection was performed, he had multiple liver metastases 2 months after the operation; he died 4 months later. Upon reviewing the medical records of our institute, we identified 4 patients who were diagnosed with adenosquamous carcinoma of the ampulla of Vater in the past 2 decades. We also identified only five reported cases of this lesion in the English literature. Adenosquamous carcinoma of the ampulla of Vater is a rare disease with a dismal prognosis. Surgical intervention does not appear to prolong patient survival. Early recurrence and distal metastasis may be encountered after surgery.
腺鳞癌被定义为组织学上具有恶性的腺和鳞状成分的肿瘤。尽管一些已发表的研究已经分析和讨论了腺鳞癌，但壶腹的混合性恶性肿瘤在文献中迄今很少被讨论。在本研究中，我们报告了一例 64 岁男性患者，其表现为黄疸和间歇性腹痛，持续数周。该患者被诊断为壶腹腺鳞癌，并接受了胰十二指肠切除术。最终诊断为壶腹腺鳞癌，T3N1M0，IIB 期。尽管进行了 R0 切除，但术后 2 个月他出现了多个肝转移；他在 4 个月后死亡。回顾我院的病历，我们发现过去 20 年来有 4 名患者被诊断为壶腹腺鳞癌。我们也仅在英文文献中发现了 5 例该病变的报道。壶腹腺鳞癌是一种罕见的疾病，预后不良。手术干预似乎并不能延长患者的生存时间。术后可能会出现早期复发和远处转移。
