Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
Cytokine. 2013 Oct;64(1):51-3. doi: 10.1016/j.cyto.2013.05.005. Epub 2013 May 27.
TNF-related apoptosis inducing ligand (TRAIL) plasma levels was measured in plasma samples obtained 1h (time 1) and 2-3 days (time 2) after delivery in a group of healthy women (n=17) who underwent cesarean delivery, and showed a significantly increase from time 1 (39.3 pg/ml median; 41.2 ± 15.9 mean ± SD) to time 2 (71.6 pg/ml median; 73.8 ± 27.8 mean ± SD). Similarly, circulating TRAIL levels were extremely low in the plasma of newborns (n=41) within the first 24h after partum (time 1; 27.5 pg/ml, median; 31.5 ± 15.8 means ± SD), showing a significant increase 2-3 days after partum (time 2; 68.4 pg/ml, median; 75.1 ± 36.7 mean ± SD). It is also noteworthy that the highest levels of plasma TRAIL were observed in newborns with the following characteristics: (i) born at later gestational age, (ii) Apgar score >9, (iii) higher birth weight, (iv) born through vaginal partum. In conclusion, we have demonstrated for the first time that the levels of circulating TRAIL are markedly low in both mothers and children after delivery, rapidly rising thereafter. Moreover, the highest levels of TRAIL are observed in newborns with the best clinical parameters.
肿瘤坏死因子相关凋亡诱导配体（TRAIL）的血浆水平在一组接受剖宫产的健康妇女（n=17）的血浆样本中进行了测量，这些妇女在分娩后 1 小时（时间 1）和 2-3 天（时间 2）获得血浆样本，结果显示，与时间 1（中位数 39.3pg/ml；平均值 ± SD 为 41.2±15.9）相比，时间 2（中位数 71.6pg/ml；平均值 ± SD 为 73.8±27.8）显著增加。同样，在分娩后 24 小时内的新生儿（n=41）的血浆中，循环 TRAIL 水平极低（时间 1；中位数 27.5pg/ml；平均值 ± SD 为 31.5±15.8），在分娩后 2-3 天内呈显著增加（时间 2；中位数 68.4pg/ml；平均值 ± SD 为 75.1±36.7）。值得注意的是，在具有以下特征的新生儿中观察到最高水平的血浆 TRAIL：（i）胎龄较大，（ii）阿普加评分>9，（iii）出生体重较高，（iv）阴道分娩。总之，我们首次证明，在分娩后，母亲和儿童的循环 TRAIL 水平明显较低，此后迅速上升。此外，在具有最佳临床参数的新生儿中观察到最高水平的 TRAIL。
