Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh 160012, India.
Int J Cardiol. 2013 Oct 3;168(3):1788-94. doi: 10.1016/j.ijcard.2013.05.013. Epub 2013 May 27.
Historically, the receptor for advanced glycation end products (RAGE) was thought to exclusively play an important role under hyperglycemic conditions. However, more and more evidence suggests that RAGE in fact is an inflammation perpetuating multi-ligand receptor and participates actively in various vascular and inflammatory diseases even in normoglycaemic conditions. Various ligands include advanced glycation end products (AGEs), S100 proteins and amphoterins etc. Besides full-length RAGE, numerous truncated forms of the receptor have also been described including the well-characterized soluble RAGE (sRAGE). sRAGE has an ability to act as a decoy to avoid interaction of RAGE with its pro-inflammatory ligands. Ligand engagement of RAGE activates multiple signaling pathways and also forms a positive feedback loop for its own enhanced expression. This review will discuss the role of multi-ligand receptor i.e. RAGE in context to various vascular diseases, which have a pathophysiologically important inflammatory component in normoglycaemic conditions.
从历史上看，晚期糖基化终产物（RAGE）受体被认为仅在高血糖条件下发挥重要作用。然而，越来越多的证据表明，RAGE 实际上是一种炎症持续存在的多配体受体，并在正常血糖条件下积极参与各种血管和炎症性疾病。各种配体包括晚期糖基化终产物（AGEs）、S100 蛋白和两性霉素等。除全长 RAGE 外，还描述了许多受体的截断形式，包括特征明确的可溶性 RAGE（sRAGE）。sRAGE 具有作为诱饵的能力，以避免 RAGE 与其促炎配体相互作用。RAGE 的配体结合激活多种信号通路，并形成自身增强表达的正反馈回路。这篇综述将讨论多配体受体（即 RAGE）在各种血管疾病中的作用，这些疾病在正常血糖条件下具有重要的病理生理学炎症成分。
