Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Arch Gynecol Obstet. 2013 Dec;288(6):1309-15. doi: 10.1007/s00404-013-2910-0. Epub 2013 May 31.
Uterine blood flow is required for the maintenance of uterine viability in pregnancy and delivery, but it is unknown how many vessels are necessary for maintenance of uterine viability. The objective of this study was to examine whether unilateral uterine vessels provide sufficient nutrition in pregnancy in a cynomolgus macaque and to evaluate hemodynamics of pregnant uterus by indocyanine green (ICG) fluorescence imaging.
A cynomolgus macaque with uterine blood flow maintained by the right uterine artery and vein alone was made pregnant. Hemodynamics of the uterus in the third trimester was evaluated by ICG fluorescence imaging.
Pregnancy was maintained with the right uterine artery and vein. An appropriate-for-date infant was delivered by Cesarean section. ICG fluorescence imaging showed that the uterine body was imaged from the right side to the center; furthermore, collateral circulation was present from the right uterine artery toward the left uterine artery, with expanded blood flow to the left uterine body.
Pregnancy and delivery were achieved in a cynomolgus macaque with a unilateral right uterine artery and vein. Blood flow to the side without the artery was complemented by vascularization of collateral circulation to the uterine artery.
子宫血流对于妊娠和分娩期间子宫的存活是必需的，但尚不清楚维持子宫存活需要多少血管。本研究旨在检查在食蟹猴中，单侧子宫血管是否能在妊娠期间提供足够的营养，并通过吲哚菁绿（ICG）荧光成像评估妊娠子宫的血液动力学。
使一只食蟹猴的右侧子宫动脉和静脉维持子宫血流，并妊娠。通过 ICG 荧光成像评估妊娠晚期子宫的血液动力学。
妊娠由右侧子宫动脉和静脉维持。通过剖宫产分娩了一个与胎龄相符的婴儿。ICG 荧光成像显示，子宫体从右侧向中心成像；此外，从右侧子宫动脉向左侧子宫动脉存在侧支循环，左侧子宫体的血流扩张。
在单侧右侧子宫动脉和静脉的食蟹猴中实现了妊娠和分娩。没有动脉的一侧的血流由侧支循环向子宫动脉的血管化来补充。
