Rudney J D
Department of Oral Science, School of Dentistry, University of Minnesota, Minneapolis 55455.
Arch Oral Biol. 1990;35(5):365-71. doi: 10.1016/0003-9969(90)90183-b.
Secretion rates (amount protein per unit time) are often used as a means of adjusting saliva protein concentrations for the effects of variation in flow rate. However, findings in olfactory physiology may indicate a problem with that approach: olfactory neurones respond differently to a small amount of odorant over a short time than to twice that quantity over twice the time, although secretion rates remain the same. Whether a similar variation in amounts and times occurs in persons with similar secretion rates for lysozyme, lactoferrin, salivary peroxidase, sIgA, or total protein in stimulated parotid saliva was investigated. The data used were from 2 groups of 44 and 198 subjects previously found to differ in flow rate and concentrations of antimicrobial proteins. Multidimensional plots of secretion rates, amounts and times were generated for each protein. Wide ranges of amounts and times were seen among persons within the same percentile for secretion rate for every protein in both groups. These amounted to as much as a thirteen-fold difference in amounts and times. Experimental studies are needed to determine whether such differences affect the action of saliva proteins.
分泌速率（单位时间内蛋白质的量）常被用作一种方法，用于根据流速变化的影响来调整唾液蛋白质浓度。然而，嗅觉生理学的研究结果可能表明这种方法存在问题：嗅觉神经元在短时间内对少量气味剂的反应与在两倍时间内对两倍量气味剂的反应不同，尽管分泌速率保持不变。本研究调查了在刺激腮腺唾液中溶菌酶、乳铁蛋白、唾液过氧化物酶、分泌型免疫球蛋白A或总蛋白分泌速率相似的人群中，是否也存在类似的量和时间变化情况。所使用的数据来自两组分别为44名和198名受试者，先前发现这两组受试者在流速和抗菌蛋白浓度方面存在差异。针对每种蛋白质生成了分泌速率、量和时间的多维图。在两组中，对于每种蛋白质，处于相同分泌速率百分位数的人群中，量和时间的范围都很广。这些量和时间的差异高达13倍。需要进行实验研究来确定这些差异是否会影响唾液蛋白质的作用。
