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人体未刺激全唾液中的抗菌蛋白相互之间的关系,以及与健康状况、牙菌斑积聚和组成的指标之间的关系。

Antimicrobial proteins in human unstimulated whole saliva in relation to each other, and to measures of health status, dental plaque accumulation and composition.

作者信息

Rudney J D, Krig M A, Neuvar E K, Soberay A H, Iverson L

机构信息

Department of Oral Science, School of Dentistry, University of Minnesota, Minneapolis 55455.

出版信息

Arch Oral Biol. 1991;36(7):497-506. doi: 10.1016/0003-9969(91)90142-h.

Abstract

Saliva antimicrobial proteins may interact in a common system to influence the oral ecology. Clinical studies of antimicrobial protein action thus may require a multiple-protein approach. Multivariate statistical methods have been used to describe possible patterns of interaction for lysozyme, lactoferrin, salivary peroxidase and secretory IgA in stimulated parotid saliva. However, oral microbes are most likely to encounter antimicrobial proteins in mixed resting saliva. Relationships among levels of lysozyme, lactoferrin, salivary peroxidase, and secretory IgA therefore were investigated in whole saliva from 216 subjects, and an attempt made to relate interperson variation in those proteins to differences in health and status, and dental plaque accumulation and composition. All proteins were significantly (alpha = 0.05) correlated with each other (r = 0.38-0.52, p less than 0.001). There was only one axis of common variation among proteins, and that axis was significantly correlated (p less than 0.001) with total protein (r = 0.84) and flow rate (r = -0.56). That pattern deviated from the previous finding that proteins of acinar origin tended to vary independently from proteins of ductal origin in stimulated parotid saliva. The difference between parotid and whole saliva may reflect constitutive secretion of all proteins at low levels of stimulation. Common variation of unstimulated saliva proteins suggests that antimicrobial actions can be compared in subjects at population extremes. There were no significant associations between antimicrobial proteins in whole saliva and measures of health status or plaque accumulation. However, the proportions of Streptococcus sanguis were significantly correlated with lysozyme (r = -0.26), lactoferrin (r = -0.34), peroxidase (r = -0.30), total protein (r = -0.37), flow rate (r = 0.24) and principal-components scores (r = -0.33) in a subset of subjects (n = 85) where commercial biochemical tests were used to supplement species identification by colony morphology. Those findings may indicate that saliva antimicrobial proteins can affect the composition of dental plaque.

摘要

唾液抗菌蛋白可能在一个共同的系统中相互作用,从而影响口腔生态。因此,抗菌蛋白作用的临床研究可能需要采用多种蛋白质的研究方法。多变量统计方法已被用于描述刺激腮腺唾液中溶菌酶、乳铁蛋白、唾液过氧化物酶和分泌型免疫球蛋白A可能的相互作用模式。然而,口腔微生物最有可能在混合的静息唾液中接触到抗菌蛋白。因此,研究了216名受试者全唾液中溶菌酶、乳铁蛋白、唾液过氧化物酶和分泌型免疫球蛋白A水平之间的关系,并试图将这些蛋白质的个体间差异与健康状况、菌斑积聚和组成的差异联系起来。所有蛋白质之间均存在显著相关性(α = 0.05)(r = 0.38 - 0.52,p < 0.001)。蛋白质之间只有一个共同变异轴,该轴与总蛋白(r = 0.84)和流速(r = -0.56)显著相关(p < 0.001)。这种模式与之前的发现不同,即在刺激腮腺唾液中,腺泡来源的蛋白质往往与导管来源的蛋白质独立变化。腮腺唾液和全唾液之间的差异可能反映了在低刺激水平下所有蛋白质的组成性分泌。未刺激唾液蛋白质的共同变异表明,可以在人群极端情况下的受试者中比较抗菌作用。全唾液中的抗菌蛋白与健康状况或菌斑积聚指标之间没有显著关联。然而,在一部分使用商业生化测试来补充通过菌落形态进行菌种鉴定的受试者(n = 85)中,血链球菌的比例与溶菌酶(r = -0.26)、乳铁蛋白(r = -0.34)、过氧化物酶(r = -0.30)、总蛋白(r = -0.37)、流速(r = 0.24)和主成分得分(r = -0.33)显著相关。这些发现可能表明唾液抗菌蛋白会影响牙菌斑的组成。

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