Department of Community Medicine, Zuoying Armed Forces General Hospital, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan.
J Occup Environ Med. 2013 Jun;55(6):614-9. doi: 10.1097/JOM.0b013e318291787a.
The aim of this study was to examine the association of lead exposure with cardiac conduction disturbance among lead-exposed and nonexposed workers in Taiwan.
The participants comprised 312 lead workers and 329 referents who had no known occupational lead exposure. During their annual health examination, they were invited to take part in the survey. Standard resting 12-lead electrocardiograms were obtained and the electrocardiographic features studied were related to blood lead levels (BLLs).
The mean BLLs were 26.05 (SD = 13.98) and 2.62 (SD = 1.42) μg/dL in lead-exposed and reference groups, respectively. Compared with the referents, lead workers had significantly shorter PR interval and longer QTc interval. Especially, workers with BLL > 30 μg/dL had the highest risk after adjusting for age, sex, body mass index, and other potential confounders.
The data suggest that lead exposure is positively associated with prolonged QTc interval.
本研究旨在探讨台湾地区铅暴露工人与非暴露工人中心脏传导障碍与铅暴露的关系。
参与者包括 312 名铅作业工人和 329 名无已知职业性铅暴露的对照者。在年度体检期间，他们被邀请参加调查。获取标准静息 12 导联心电图，并研究心电图特征与血铅水平（BLL）的关系。
暴露组和对照组的平均 BLL 分别为 26.05（SD=13.98）和 2.62（SD=1.42）μg/dL。与对照组相比，铅作业工人的 PR 间期明显缩短，QTc 间期延长。特别是，在校正年龄、性别、体重指数和其他潜在混杂因素后，BLL＞30μg/dL 的工人风险最高。
数据表明，铅暴露与 QTc 间期延长呈正相关。
