Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.
Macromol Rapid Commun. 2013 Jul 12;34(13):1062-6. doi: 10.1002/marc.201300324. Epub 2013 May 31.
Macroscopic pH-responsive self-assembly is successfully constructed by polyacrylamide(pAAm)-based gels carrying dansyl (Dns) and β-cyclodextrin (βCD) residues, which are represented as Dns-gel and βCD-gel, respectively. Dns-gel and βCD-gel assemble together at pH ≥ 4.0, but disassemble at pH ≤ 3.0. The adhesion strengths for pairs of Dns-gel/βCD-gel increase with increasing pH. The fluorescence study on the model system of pAAm modified with 1 mol% Dns moieties (pAAm/Dns) reveals that Dns residues are protonated at a lower pH, which results in the reduction in binding constant (K) for Dns residues and βCD.
通过携带丹磺酰基（Dns）和β-环糊精（βCD）残基的聚丙烯酰胺（pAAm）基凝胶成功构建了宏观 pH 响应自组装，分别表示为 Dns-凝胶和βCD-凝胶。在 pH≥4.0 时，Dns-凝胶和βCD-凝胶组装在一起，但在 pH≤3.0 时则解组装。Dns-凝胶/βCD-凝胶对的粘附强度随 pH 的增加而增加。对用 1 mol%Dns 部分（pAAm/Dns）修饰的 pAAm 的模型体系的荧光研究表明，Dns 残基在较低的 pH 下质子化，这导致 Dns 残基和βCD 的结合常数（K）降低。
