• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

嗜冷解糖芽孢杆菌的基因组，一种用于工业核苷合成的2'-脱氧核糖基转移酶的潜在来源。

Genome of the Psychrophilic Bacterium Bacillus psychrosaccharolyticus, a Potential Source of 2'-Deoxyribosyltransferase for Industrial Nucleoside Synthesis.

作者信息

Fresco-Taboada Alba, Del Cerro Carlos, Fernández-Lucas Jesús, Arroyo Miguel, Acebal Carmen, García José L, de la Mata Isabel

机构信息

Department of Biochemistry and Molecular Biology, Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain.

出版信息

Genome Announc. 2013 May 30;1(3):e00309-13. doi: 10.1128/genomeA.00309-13.

DOI:10.1128/genomeA.00309-13
PMID:23723405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3668013/
Abstract

Here we report the draft genome sequence of Bacillus psychrosaccharolyticus, a cold-adapted bacterium with biotechnological interest. The genome contains genes related to the ability of this microorganism to grow at low temperatures and includes a nucleoside 2'-deoxyribosyltransferase, which can be used in the industrial synthesis of modified nucleosides with therapeutic activity.

摘要

在此，我们报告了嗜冷解糖芽孢杆菌的基因组序列草图，这是一种具有生物技术应用价值的嗜冷细菌。该基因组包含与这种微生物在低温下生长能力相关的基因，并且包括一种核苷2'-脱氧核糖基转移酶，其可用于具有治疗活性的修饰核苷的工业合成。

相似文献

1
Genome of the Psychrophilic Bacterium Bacillus psychrosaccharolyticus, a Potential Source of 2'-Deoxyribosyltransferase for Industrial Nucleoside Synthesis.嗜冷解糖芽孢杆菌的基因组，一种用于工业核苷合成的2'-脱氧核糖基转移酶的潜在来源。
Genome Announc. 2013 May 30;1(3):e00309-13. doi: 10.1128/genomeA.00309-13.
2
Nucleoside 2'-deoxyribosyltransferase from psychrophilic bacterium Bacillus psychrosaccharolyticus--preparation of an immobilized biocatalyst for the enzymatic synthesis of therapeutic nucleosides.嗜冷菌解糖嗜冷芽孢杆菌的核苷2'-脱氧核糖基转移酶——用于治疗性核苷酶促合成的固定化生物催化剂的制备
Molecules. 2014 Jul 31;19(8):11231-49. doi: 10.3390/molecules190811231.
3
Structure and function of L-lactate dehydrogenases from thermophilic, mesophilic and psychrophilic bacteria, IX. Identification, isolation and nucleotide sequence of two L-lactate dehydrogenase genes of the psychrophilic bacterium Bacillus psychrosaccharolyticus.嗜热、嗜温和嗜冷细菌L-乳酸脱氢酶的结构与功能，IX.嗜冷解糖芽孢杆菌两个L-乳酸脱氢酶基因的鉴定、分离及核苷酸序列
Biol Chem Hoppe Seyler. 1990 Feb;371(2):103-10. doi: 10.1515/bchm3.1990.371.1.103.
4
High catalytic activity of alanine racemase from psychrophilic Bacillus psychrosaccharolyticus at high temperatures in the presence of pyridoxal 5'-phosphate.嗜冷性解糖芽孢杆菌的丙氨酸消旋酶在高温及磷酸吡哆醛存在下具有高催化活性。
FEMS Microbiol Lett. 2000 Nov 15;192(2):169-73. doi: 10.1111/j.1574-6968.2000.tb09377.x.
5
2'-Deoxyribosyltransferase from Leishmania mexicana, an efficient biocatalyst for one-pot, one-step synthesis of nucleosides from poorly soluble purine bases.来源于墨西哥利什曼原虫的 2'-脱氧核糖基转移酶，是一种高效的生物催化剂，可用于从难溶性嘌呤碱基一锅、一步合成核苷。
Appl Microbiol Biotechnol. 2017 Oct;101(19):7187-7200. doi: 10.1007/s00253-017-8450-y. Epub 2017 Aug 7.
6
The primary structure of the psychrophilic lactate dehydrogenase from Bacillus psychrosaccharolyticus.嗜冷解糖芽孢杆菌嗜冷乳酸脱氢酶的一级结构。
Biol Chem Hoppe Seyler. 1987 Nov;368(11):1435-46. doi: 10.1515/bchm3.1987.368.2.1435.
7
Psychrophilicity of Bacillus psychrosaccharolyticus: a proteomic study.解糖嗜冷芽孢杆菌的嗜冷性：一项蛋白质组学研究。
Proteomics. 2004 Nov;4(11):3654-9. doi: 10.1002/pmic.200401025.
8
Immobilized enzyme reactors based on nucleoside phosphorylases and 2'-deoxyribosyltransferase for the in-flow synthesis of pharmaceutically relevant nucleoside analogues.基于核苷磷酸化酶和 2'-脱氧核糖基转移酶的固定化酶反应器，用于流动相中合成具有药用价值的核苷类似物。
Bioresour Technol. 2020 Jul;307:123258. doi: 10.1016/j.biortech.2020.123258. Epub 2020 Mar 26.
9
Establishment of a high throughput-screening system for nucleoside deoxyribosyltransferase II mutant enzymes with altered substrate specificity.建立一种高通量筛选系统，用于研究具有改变的底物特异性的核苷脱氧核糖基转移酶 II 突变酶。
J Biosci Bioeng. 2019 Jul;128(1):22-27. doi: 10.1016/j.jbiosc.2019.01.002. Epub 2019 Feb 23.
10
Draft Genome Sequence of Permafrost Bacterium sp. Strain PF2B19, Revealing a Cold Adaptation Strategy and Diverse Biotechnological Potential.永冻土细菌菌株PF2B19的基因组序列草图，揭示了一种冷适应策略和多样的生物技术潜力。
Genome Announc. 2017 Apr 13;5(15):e00133-17. doi: 10.1128/genomeA.00133-17.

引用本文的文献

1
Microbial adaptation to different environmental conditions: molecular perspective of evolved genetic and cellular systems.微生物对不同环境条件的适应：进化遗传和细胞系统的分子视角。
Arch Microbiol. 2022 Jan 19;204(2):144. doi: 10.1007/s00203-022-02757-5.
2
Nucleoside 2'-deoxyribosyltransferase from psychrophilic bacterium Bacillus psychrosaccharolyticus--preparation of an immobilized biocatalyst for the enzymatic synthesis of therapeutic nucleosides.嗜冷菌解糖嗜冷芽孢杆菌的核苷2'-脱氧核糖基转移酶——用于治疗性核苷酶促合成的固定化生物催化剂的制备
Molecules. 2014 Jul 31;19(8):11231-49. doi: 10.3390/molecules190811231.

本文引用的文献

1
Biotechnological uses of enzymes from psychrophiles.嗜冷菌酶的生物技术应用。
Microb Biotechnol. 2011 Jul;4(4):449-60. doi: 10.1111/j.1751-7915.2011.00258.x. Epub 2011 Mar 24.
2
A 40-year journey in search of selective antiviral chemotherapy.四十载探索之路，寻觅选择性抗病毒化疗。
Annu Rev Pharmacol Toxicol. 2011;51:1-24. doi: 10.1146/annurev-pharmtox-010510-100228.
3
Innovations and opportunities to improve conventional (deoxy)nucleoside and fluoropyrimidine analogs in cancer.癌症中常规（脱氧）核苷和氟嘧啶类似物的创新和改进机会。
Curr Med Chem. 2009;16(35):4632-43. doi: 10.2174/092986709789878229.
4
The RAST Server: rapid annotations using subsystems technology.RAST服务器：使用子系统技术进行快速注释。
BMC Genomics. 2008 Feb 8;9:75. doi: 10.1186/1471-2164-9-75.
5
Coping with cold: the genome of the versatile marine Antarctica bacterium Pseudoalteromonas haloplanktis TAC125.应对寒冷：多功能海洋南极细菌嗜盐栖假交替单胞菌TAC125的基因组
Genome Res. 2005 Oct;15(10):1325-35. doi: 10.1101/gr.4126905. Epub 2005 Sep 16.
6
The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses.通过基因组和蛋白质组分析，嗜冷红杆菌34H的基因组序列所揭示的嗜冷生活方式。
Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10913-8. doi: 10.1073/pnas.0504766102. Epub 2005 Jul 25.
7
The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments.嗜冷脱硫菌的基因组，一种来自常年寒冷的北极沉积物的硫酸盐还原菌。
Environ Microbiol. 2004 Sep;6(9):887-902. doi: 10.1111/j.1462-2920.2004.00665.x.
8
Mechanisms of thermal adaptation revealed from the genomes of the Antarctic Archaea Methanogenium frigidum and Methanococcoides burtonii.从南极古菌嗜冷产甲烷菌和伯氏甲烷球菌基因组揭示的热适应机制。
Genome Res. 2003 Jul;13(7):1580-8. doi: 10.1101/gr.1180903. Epub 2003 Jun 12.
9
Bacterial cold-shock proteins.细菌冷休克蛋白
Cell Mol Life Sci. 2002 Nov;59(11):1902-13. doi: 10.1007/pl00012513.
10
Low-temperature extremophiles and their applications.低温极端微生物及其应用。
Curr Opin Biotechnol. 2002 Jun;13(3):253-61. doi: 10.1016/s0958-1669(02)00317-8.