Low vitamin D concentration is not associated with increased mortality and morbidity after cardiac surgery.

OBJECTIVE

To determine the effect of vitamin D on postoperative outcomes in cardiac surgical patients.

DESIGN

Retrospective study.

SETTING

Single institution-teaching hospital.

PARTICIPANTS

Adult cardiac surgical patients with perioperative 25-hydroxyvitamin D measurements.

INTERVENTIONS

None. We gathered information from the Cardiac Anesthesiology Registry that was obtained at the time of the patients' visit/hospitalization.

MEASUREMENTS AND MAIN RESULTS

We used data of 18,064 patients from the Cardiac Anesthesiology Registry; 426 patients with 25-hydroxyvitamin D measurements met our inclusion criteria. Association with Vitamin D concentration and composite of 11 cardiac morbidities was done by multivariate (i.e., multiple outcomes per subject) analysis. For other outcomes separate multivariable logistic regressions and adjusting for the potential confounders was used. The observed median vitamin D concentration was 19 [Q1-Q3∶12, 30] ng/mL. Vitamin D concentration was not associated with our primary composite of serious cardiac morbidities (odds ratio [OR], 0.96; 95% CI, 0.86-1.07). Vitamin D concentration was also not associated with any of the secondary outcomes: neurologic morbidity (P = 0.27), surgical (P = 0.26) or systemic infections (P = 0.58), 30-day mortality (P = 0.55), or length of initial intensive care unit (ICU) stay (P = 0.04).

CONCLUSIONS

Our analysis suggests that perioperative vitamin D concentration is not associated with clinically important outcomes, likely because the outcomes are overwhelmingly determined by other baseline and surgical factors.