Zhang Ling, Mai Hua-Ming, Zheng Jing, Zheng Jia-Wei, Chen Zheng-Gang, Wang Yan-An, Qin Zhong-Ping, Li Ke-Lei, Yuan Wei-En
Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology Shanghai 200011, PR China.
Int J Clin Exp Med. 2013 May 22;6(5):342-5. Print 2013.
Propranolol (PRN) has recently been recommended as the first-line medicine for complicated infantile hemangiomas (IHs), because of the significant effect. However, no pharmacokinetic parameters have ever been reported for infants who receive PRN treatment for IH. In this study, we show that plasma PRN concentration is affected by the frequency of administration of PRN. A single daily administration of PRN (1 mg/kg/d) resulted in an early elevation of plasma PRN compared to a twice a day administration of the same dose. In contrast, the twice a day application resulted in a more prolonged expression at a later time-point. Our findings provide pharmacokinetic parameters of PRN action in IH for clinic.
普萘洛尔（PRN）最近因其显著疗效而被推荐作为治疗复杂性婴儿血管瘤（IH）的一线药物。然而，对于接受PRN治疗IH的婴儿，尚未有药代动力学参数的报道。在本研究中，我们发现血浆PRN浓度受PRN给药频率的影响。与相同剂量每日两次给药相比，每日一次给予PRN（1 mg/kg/d）导致血浆PRN早期升高。相反，每日两次给药在后期导致表达时间更长。我们的研究结果为临床提供了PRN治疗IH的药代动力学参数。
