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本文引用的文献

1
Argininosuccinate synthase: at the center of arginine metabolism.精氨琥珀酸合成酶：处于精氨酸代谢的中心
Int J Biochem Mol Biol. 2011;2(1):8-23.
2
Inhibition of LPS toxicity by hepatic argininosuccinate synthase (ASS): novel roles for ASS in innate immune responses to bacterial infection.肝精氨酸琥珀酸合成酶（ASS）抑制 LPS 毒性：ASS 在细菌感染固有免疫反应中的新作用。
Int Immunopharmacol. 2011 Sep;11(9):1180-8. doi: 10.1016/j.intimp.2011.03.016. Epub 2011 Apr 7.
3
Intestinal glucose uptake protects liver from lipopolysaccharide and D-galactosamine, acetaminophen, and alpha-amanitin in mice.肠道葡萄糖摄取可保护小鼠肝脏免受脂多糖、D-半乳糖胺、对乙酰氨基酚和α-鹅膏蕈碱的损伤。
Am J Pathol. 2009 Sep;175(3):1066-76. doi: 10.2353/ajpath.2009.090071. Epub 2009 Aug 21.
4
Identification and preliminary validation of novel biomarkers of acute hepatic ischaemia/reperfusion injury using dual-platform proteomic/degradomic approaches.使用双平台蛋白质组学/降解组学方法鉴定急性肝缺血/再灌注损伤新生物标志物并进行初步验证。
Biomarkers. 2006 Jul-Aug;11(4):355-69. doi: 10.1080/13547500600775110.
5
Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle.从尿素循环到瓜氨酸-一氧化氮循环的精氨琥珀酸合成酶。
Eur J Biochem. 2003 May;270(9):1887-99. doi: 10.1046/j.1432-1033.2003.03559.x.
6
Glutathione S-transferase: a potential new marker of intestinal ischemia.谷胱甘肽S-转移酶：一种潜在的肠缺血新标志物。
J Pediatr Surg. 2002 Nov;37(11):1543-8. doi: 10.1053/jpsu.2002.36181.
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Alpha-glutathione S-transferase in the assessment of hepatotoxicity--its diagnostic utility in comparison with other recognized markers in the Wistar Han rat.α-谷胱甘肽S-转移酶在肝毒性评估中的作用——与Wistar Han大鼠中其他公认标志物相比的诊断效用
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8
Stochastic estimates of exposure and cancer risk from carbon tetrachloride released to the air from the rocky flats plant.
Risk Anal. 2001 Aug;21(4):675-95. doi: 10.1111/0272-4332.214143.
9
Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects.人类胞质磺基转移酶：遗传学、特性、毒理学方面
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10
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ASS和SULT2A1是急性肝损伤的新型敏感生物标志物——动物模型中的比较研究。

ASS and SULT2A1 are Novel and Sensitive Biomarkers of Acute Hepatic Injury-A Comparative Study in Animal Models.

作者信息

Prima Victor, Cao Mengde, Svetlov Stanislav I

机构信息

Banyan Laboratories, Inc., Alachua, FL, USA.

出版信息

J Liver. 2013 Jan 10;2(1). doi: 10.4172/2167-0889.1000115.

DOI:10.4172/2167-0889.1000115
PMID:23724364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3665291/
Abstract

Liver and kidney damage associated with polytrauma, endotoxic shock/sepsis, and organ transplantation, are among the leading causes of the multiple organ failure. Development of novel sensitive biomarkers that detect early stages of liver and kidney injury is vital for the effective diagnostics and treatment of these life-threatening conditions. Previously, we identified several hepatic proteins, including Argininosuccinate Synthase (ASS) and sulfotransferases which were degraded in the liver and rapidly released into circulation during Ischemia/Reperfusion (I/R) injury. Here we compared sensitivity and specificity of the newly developed sandwich ELISA assays for ASS and the sulfotransferase isoform SULT2A1 with the standard clinical liver and kidney tests Alanine Aminotransferase (ALT) and Aspartate Transaminase (AST) in various pre-clinical models of acute injury. Our data suggest that ASS and SULT2A1 have superior characteristics for liver and kidney health assessment in endotoxemia, Ischemia/Reperfusion (I/R), chemical and drug-induced liver injury and may be of high potential value for clinical applications.

摘要

与多发伤、内毒素休克/脓毒症及器官移植相关的肝损伤和肾损伤，是多器官功能衰竭的主要原因之一。开发能够检测肝损伤和肾损伤早期阶段的新型敏感生物标志物，对于有效诊断和治疗这些危及生命的病症至关重要。此前，我们鉴定了几种肝脏蛋白，包括精氨琥珀酸合成酶（ASS）和磺基转移酶，它们在肝脏中降解，并在缺血/再灌注（I/R）损伤期间迅速释放到循环中。在此，我们在各种急性损伤的临床前模型中，将新开发的针对ASS和磺基转移酶同工型SULT2A1的夹心ELISA检测方法的敏感性和特异性，与标准临床肝脏和肾脏检测指标丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）进行了比较。我们的数据表明，ASS和SULT2A1在内毒素血症、缺血/再灌注（I/R）、化学及药物诱导的肝损伤中，对肝脏和肾脏健康评估具有卓越特性，可能具有很高的临床应用价值。