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患有儿童期慢性病的年轻成年男性的生殖健康。

Reproductive health in young male adults with chronic diseases in childhood.

作者信息

De Sanctis Vincenzo, Soliman Ashraf, Mohamed Yassin

机构信息

Pediatric and Adolescent Outpatient Clinic, Quisisana Hospital, Ferrara, Italy.

出版信息

Pediatr Endocrinol Rev. 2013 Mar-Apr;10(3):284-96.

Abstract

The Centres for Disease Control and Prevention have defined a chronic diseases as an "illnesses that are prolonged, do not resolve spontaneously, and are rarely cured completely". Approximately 20% of all children have a chronic illness and 65% of them the illness is severe enough to interfere with daily activities. Failure of pubertal growth, delay or absence of sexual development, infertility and sexual dysfunction due to hypogonadism and defective spermatogenesis are well recognized disturbances among adolescents and young male adult patients with chronic diseases. The causes are multifactorial and can be due to disease itself, associated complications or drugs. Haemoglobinopathies, endocrine disorders, gastrointestinal and renal diseases are some examples that frequently cause some degree of disability. Infertility affects the future quality of life of these patients and is a predictor of stress in current and future relationships. Health care providers often neglect the reproductive health of chronically ill adolescents and young adults, although many studies indicate that they are sexually active and interested in knowing about their future fertility. This review article provides an overview of the literature concerning the impact of some chronic diseases in adolescents and young adults on reproductive health but will not address patients with cancer because it has been tackled adequately in the literature.MEDLINE database search of English-language medical journal articles published between 1975 and 2012 for papers related to reproductive health in adolescents and young adults with chronic diseases since childhood was done. Several Authors, recommend that all young adult patients with severe/prolonged chronic disease in childhood should be offered reproductive health care in a specialized center with appropriate expertise, involving a multidisciplinary team, including endocrinologists, andrologists, geneticists, psychologists, urologists and specialist nurses. Adequate information must be provided to these patients about adolescent reproductive health, including types of contraception, pregnancy, sexually transmitted infections and fertility. The importance of transitional care between pediatric and adult medical care should not be ignored. In the development of this process the adolescent must be involved in decision-making regarding treatment or referral. Reproductive health medicine should take a wider view to create a physical, psychological and genetic wellbeing of these patients.

摘要

疾病控制与预防中心将慢性病定义为“病程漫长、无法自愈且极少能完全治愈的疾病”。约20%的儿童患有慢性病,其中65%的病情严重到足以影响日常活动。青春期生长发育障碍、性发育延迟或缺失、性腺功能减退和精子发生缺陷导致的不育及性功能障碍,是患有慢性病的青少年和年轻成年男性患者中广为人知的病症。病因是多方面的,可能源于疾病本身、相关并发症或药物。血红蛋白病、内分泌失调、胃肠道和肾脏疾病就是一些常导致某种程度残疾的例子。不育会影响这些患者未来的生活质量,也是当前及未来人际关系中压力的一个预测因素。尽管许多研究表明慢性病青少年和年轻成年人有性活动且对了解自己未来的生育能力感兴趣,但医疗服务提供者往往忽视他们的生殖健康。这篇综述文章概述了有关青少年和年轻成年人的某些慢性病对生殖健康影响的文献,但不涉及癌症患者,因为该领域在文献中已有充分论述。通过检索MEDLINE数据库,查找1975年至2012年间发表的与自幼患有慢性病的青少年和年轻成年人的生殖健康相关的英文医学期刊文章。几位作者建议,所有童年时期患有严重/长期慢性病的年轻成年患者,都应在具备适当专业知识的专门中心接受生殖健康护理,该中心要有多学科团队参与,包括内分泌学家、男科学家、遗传学家、心理学家、泌尿科医生和专科护士。必须向这些患者提供有关青少年生殖健康的充分信息,包括避孕方式、怀孕、性传播感染和生育能力等。儿科与成人医疗护理之间过渡性护理的重要性不可忽视。在这个过程的发展中,青少年必须参与有关治疗或转诊的决策。生殖健康医学应从更广泛的角度出发,为这些患者创造身体、心理和基因方面的健康状态。

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