Kishi K, Peng J Y, Kakuta S, Murakami K, Kuroda M, Yokota S, Hayakawa S, Kuge T, Asayama T
Department of Anatomy, Toho University School of Medicine, Tokyo, Japan.
Arch Histol Cytol. 1990 May;53(2):219-26. doi: 10.1679/aohc.53.219.
In order to examine the relationship between radial glial fibers and the migrating bipolar subependymal cells which are considered to be post-mitotic precursors of granule cells in the rat olfactory bulb, the arrangement of radial glial fibers along the anterior lateral and olfactory ventricles was analysed by Golgi techniques, immunohistochemical demonstration of glial fibrillary acidic protein, and electron microscopy. In rats during their first 3 weeks of life, the bipolar subependymal cells migrate along the anterior lateral and olfactory ventricles into the center of the olfactory bulb, whereas the radial glial fibers radiating from the ventricular surface are arranged rather perpendicularly to the direction of migration of bipolar cells. Hence radial glial fibers in this region are not considered to act as guides for the rostralwards migration of subependymal cells.
为了研究放射状胶质纤维与迁移的双极室管膜下细胞之间的关系，后者被认为是大鼠嗅球颗粒细胞有丝分裂后的前体细胞，我们通过高尔基染色技术、胶质纤维酸性蛋白的免疫组织化学显示以及电子显微镜分析了沿前外侧脑室和嗅脑室排列的放射状胶质纤维。在出生后前三周的大鼠中，双极室管膜下细胞沿前外侧脑室和嗅脑室迁移至嗅球中心，而从脑室表面发出的放射状胶质纤维的排列方向与双极细胞的迁移方向相当垂直。因此，该区域的放射状胶质纤维不被认为是室管膜下细胞向吻侧迁移的引导物。
