Yin Xue-Jiao, Sun Wei, Wan Yi-Gang, Tu Yue, Liu Hong, Yu Bing-Yin
Nanjing University of Chinese Medicine, Nanjing 210029, China.
Zhongguo Zhong Yao Za Zhi. 2013 Mar;38(5):648-52.
Epithelial to mesenchymal transition (EMT) has been proposed as a key role leading to the progressive tubulo-interstitial fibrosis (TIF). The tubular EMT is an highly regulated process involving four key steps including: loss of epithelial cell adhesion, de novo smooth muscle actin expression and actin reorganization, disruption of tubular basement membrane,and enhanced cell migration and invasion. These crucial processes are closely connected to the relative actions on many signaling pathways in EMT. Additionally, increasing evidences suggest that some Chinese herbal medicines and their extracts, such as Astragali Radix, Cordyceps, Salvia miltiorrhiza, as well as Chinese. herbal prescriptions including Astragalus Angelica mixture and Supplementing Qi and activating blood circulation decoction, could intervene the related events controlling EMT both in vitro and in vivo. Chinese herbal medicines could ameliorate TIF by intervening the course of EMT.
上皮-间质转化（EMT）被认为是导致进行性肾小管间质纤维化（TIF）的关键因素。肾小管EMT是一个高度调控的过程，涉及四个关键步骤，包括：上皮细胞黏附丧失、平滑肌肌动蛋白的从头表达和肌动蛋白重组、肾小管基底膜破坏以及细胞迁移和侵袭增强。这些关键过程与EMT中许多信号通路的相关作用密切相关。此外，越来越多的证据表明，一些中药及其提取物，如黄芪、冬虫夏草、丹参，以及包括黄芪当归合剂和益气活血汤在内的中药方剂，在体外和体内均可干预控制EMT的相关事件。中药可通过干预EMT过程来改善TIF。
