Wang Chaojun, Wan Yigang, Luo Xunyang, Dou Chenhui, Feng Qing, Yan Qiaojing, Yao Jian
Nanjing Drum Tower Hospital Clinical College of Traditional Chinese Medicine and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China.
Zhongguo Zhong Yao Za Zhi. 2011 Jan;36(1):85-91.
In kidney, the role of cell proliferation, differentiation, apoptosis, inflammatory mediators and cytokines expression is closely related with cell signaling pathways, including tyrosine kinase pathway, transforming growth factor-beta/Smad pathway, Rho/Rho-associated coiled-coil forming protein kinase pathway, phosphoinositol pathway, cyclic nucleotide pathway, nuclear factor kappaB pathway and so on. Some Chinese herbs and their extracts, such as rhubarb and triptolide, as well as some Chinese herbal prescriptions, such as astragalus-angelica mixture and Chailing decoction, not only could ameliorate proliferation, differentiation and apoptosis of renal cell by regulating cell signaling pathways, but also could control target gene transcription, expression and its biological effects through inhibiting the phosphorylation of key signaling molecules.
在肾脏中，细胞增殖、分化、凋亡、炎症介质和细胞因子表达的作用与细胞信号通路密切相关，这些信号通路包括酪氨酸激酶通路、转化生长因子-β/Smad通路、Rho/Rho相关卷曲螺旋形成蛋白激酶通路、磷酸肌醇通路、环核苷酸通路、核因子κB通路等。一些中药及其提取物，如大黄和雷公藤内酯醇，以及一些中药复方，如黄芪当归合剂和柴苓汤，不仅可以通过调节细胞信号通路改善肾细胞的增殖、分化和凋亡，还可以通过抑制关键信号分子的磷酸化来控制靶基因的转录、表达及其生物学效应。
