通过氨基烯炔催化不对称合成类似药物的六元稠合螺环氧化吲哚。
Asymmetric synthesis of druglike six-membered spirooxindoles through an amino enyne catalysis.
机构信息
Catalysis Laboratory, School of Chemistry, University of Hyderabad , Central University (PO), Hyderabad 500 046, India.
出版信息
Org Lett. 2013 Jun 21;15(12):3042-5. doi: 10.1021/ol401227q. Epub 2013 May 31.
PMID:23724824
Abstract
An effective reflexive-Michael (r-M) reaction has been disclosed to access drug-like six-membered spirooxindoles in good yields and excellent enantioselectivities by using an aminoenyne-catalysis.
摘要
本文报道了一种有效的迈克尔（r-M）反应，通过氨基烯炔催化，可以以良好的收率和优异的对映选择性获得类似药物的六元稠合螺环氧化吲哚。
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