Kuboi Toru, Kusaka Takashi, Kawada Koh, Koyano Kousuke, Nakamura Shinji, Okubo Kensuke, Yasuda Saneyuki, Isobe Kenichi, Itoh Susumu
Maternal Perinatal Center, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Pediatr Int. 2013 Oct;55(5):608-11. doi: 10.1111/ped.12149. Epub 2013 Aug 21.
The measurement of transcutaneous bilirubin (TcB) is very important to screen for hyperbilirubinemia in newborns. Until now, however, there has been no hour-specific, percentile-based TcB nomogram during the early neonatal period in Japanese neonates. The aim of this study was to develop a TcB nomogram within 72 h of birth in Japanese neonates.
A total of 3152 TcB measurements for 181 healthy Japanese neonates (gestational age ≥36 weeks, birthweight ≥2300 g) were obtained within 72 h of birth. All measurements were performed with a Konica Minolta jaundice meter, the JM-103. A nomogram curve was plotted to show the trend of TcB level over time.
The nomogram curves rose almost linearly for all percentiles until 72 h after birth.
An hour-specific, percentile-based TcB nomogram during the first 72 h after birth in Japanese neonates was successfully developed. Because Japanese neonates have higher and later peak bilirubin, an original hour-specific 97.5th percentile-based TcB nomogram may be needed to identify early-onset jaundice and manage neonatal hyperbilirubinemia.
经皮胆红素（TcB）测量对于新生儿高胆红素血症的筛查非常重要。然而，迄今为止，日本新生儿在新生儿早期尚无基于小时和百分位数的TcB列线图。本研究的目的是为日本新生儿绘制出生72小时内的TcB列线图。
在出生72小时内，共获得181名健康日本新生儿（胎龄≥36周，出生体重≥2300克）的3152次TcB测量值。所有测量均使用柯尼卡美能达黄疸仪JM - 103进行。绘制列线图曲线以显示TcB水平随时间的变化趋势。
直到出生后72小时，所有百分位数的列线图曲线几乎呈线性上升。
成功绘制了日本新生儿出生后前72小时基于小时和百分位数的TcB列线图。由于日本新生儿胆红素峰值出现得更高且更晚，可能需要一个基于小时的原始第97.5百分位数的TcB列线图来识别早发性黄疸并管理新生儿高胆红素血症。
