Department of Pediatrics, Faculty of Medicine, Kagawa University.
Department of Hygiene, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Pediatr Int. 2020 Sep;62(9):1049-1053. doi: 10.1111/ped.14251. Epub 2020 Sep 14.
Neonatal hyperbilirubinemia is a significant health problem in Myanmar, and the rate of kernicterus is also higher than in developed countries. Non-invasive methods for early detection and treatment of hyperbilirubinemia are urgently needed. In this study, we used transcutaneous bilirubin (TcB) measurements to develop an hour-specific TcB nomogram for the effective management of hyperbilirubinemia in Myanmar newborns.
The bilirubin levels of neonates born in Central Women Hospital in Yangon, Myanmar were measured three times a day within 72 h after birth using a transcutaneous bilirubinometer. An hour-specific TcB nomogram was created based on the data.
Participants were 512 infants (287 boys, 225 girls) born in Central Women's Hospital in Yangon. The mean (±SD) gestational age was 38.4 ± 1.2 weeks; birthweight was 3078 ± 412 g. A total of 3,039 plots were obtained, and the TcB nomogram was created with smoothed percentile curves (97.5th, 50th, and 2.5th percentiles) for 0-72 h after birth.
An hour-specific TcB nomogram was successfully created to manage hyperbilirubinemia in Myanmar newborns.
新生儿高胆红素血症是缅甸的一个重大健康问题，核黄疸的发病率也高于发达国家。迫切需要非侵入性的方法来早期检测和治疗高胆红素血症。在这项研究中，我们使用经皮胆红素（TcB）测量值为缅甸新生儿制定了一个小时特异性的 TcB 图表，以有效管理高胆红素血症。
在缅甸仰光中央妇女医院出生的新生儿在出生后 72 小时内每天测量三次 TcB，使用经皮胆红素计。根据数据制定了一个小时特异性的 TcB 图表。
参与者为 512 名婴儿（287 名男孩，225 名女孩），均在仰光中央妇女医院出生。平均（±SD）胎龄为 38.4±1.2 周；出生体重为 3078±412 克。共获得 3039 个数据点，为出生后 0-72 小时创建了 TcB 图表，具有平滑的百分位数曲线（97.5 百分位、50 百分位和 2.5 百分位）。
成功为缅甸新生儿制定了一个小时特异性的 TcB 图表来管理高胆红素血症。
