Bhatia Shilpa, Menezes Mitchell E, Das Swadesh K, Emdad Luni, Dasgupta Santanu, Wang Xiang-Yang, Sarkar Devanand, Fisher Paul B
Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA.
Discov Med. 2013 May;15(84):309-17.
Gene therapy provides a novel platform for therapeutic intervention of several genetic and non-genetic disorders. With the recent developments in the field, a wide variety of viral and non-viral vectors have emerged that can deliver genetic payloads to target cells. However, non-targeted delivery of transgenes often results in undesirable effects, low tumor transduction, and reduced therapeutic index. In this review, we focus on some of the novel approaches that can be used to meet the present challenges in the field and translate the potential of cancer gene therapy from 'bench to bedside' in the near future.
基因治疗为多种遗传和非遗传疾病的治疗干预提供了一个新的平台。随着该领域的最新发展，出现了各种各样的病毒和非病毒载体，它们可以将基因载荷传递到靶细胞。然而，转基因的非靶向递送常常导致不良影响、低肿瘤转导率和降低的治疗指数。在这篇综述中，我们重点关注一些可用于应对该领域当前挑战的新方法，并在不久的将来将癌症基因治疗的潜力从“实验室”转化为“临床应用”。
