Niut Yuting, Popatt Amirali, Yu Meihua, Karmakar Surajit, Gu Wenyi, Yu Chengzhong
Australian Institute for Bioengineering & Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
Ther Deliv. 2012 Oct;3(10):1217-37.
Gene therapy has attracted much attention in modern society and provides a promising approach for treating genetic disorders, diseases and cancers. Safe and effective vectors are vital tools to deliver genetic molecules to cells. This review summarizes recent advances in the rational design of silica-based nanoparticles and their applications in gene therapy. An overview of different types of genetic agents available for gene therapy is provided. The engineering of various silica nanoparticles is described, which can be used as versatile complexation tools for genetic agents and advanced gene therapy. Several challenges are raised and future research directions in the area of gene therapy using silica-based nanoparticles are proposed.
基因治疗在现代社会备受关注，并为治疗遗传疾病、病症和癌症提供了一种有前景的方法。安全有效的载体是将遗传分子递送至细胞的关键工具。本综述总结了基于二氧化硅的纳米颗粒合理设计及其在基因治疗中的应用的最新进展。提供了可用于基因治疗的不同类型遗传制剂的概述。描述了各种二氧化硅纳米颗粒的工程设计，其可用作遗传制剂和先进基因治疗的通用络合工具。提出了若干挑战，并给出了基于二氧化硅纳米颗粒的基因治疗领域未来的研究方向。
