Healthy Heart Program Prevention Clinic, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Vancouver, British Columbia, Canada.
J Clin Lipidol. 2013 May-Jun;7(3):194-8. doi: 10.1016/j.jacl.2013.02.003. Epub 2013 Feb 26.
Diabetes mellitus and low levels of high-density lipoprotein cholesterol (HDL-C) are among several known risk factors for coronary artery disease. Recent research has shown potential mechanistic links between these two diseases.
The aim of our study was to characterize, by examining particular coronary artery disease risk factors, patients with extremely high and low levels of HDL-C who were referred to a prevention clinic.
We compared the phenotypes of 113 patients with HDL-C levels greater than the 90th percentile with 212 patients with levels less than the 10th percentile by using a retrospective chart review.
The cohort with high HDL-C had a remarkable difference in the incidence of type 2 diabetes (1.8% vs 21.7%). The high HDL-C cohort also had a greater age (52.1 years vs 46.7 years), more light or moderate alcohol consumption (70.8% vs 49.4%), more healthy diet (30.1% vs 22.4%), more light or moderate exercise (90.8% vs 52.2%), and a lower body mass index (25.2 kg/m² vs 28.1 kg/m²).
Compared with the low HDL-C group--and also the general population--the high HDL-C cohort had a remarkably low prevalence of diabetes mellitus.
糖尿病和低水平的高密度脂蛋白胆固醇（HDL-C）是几种已知的冠心病风险因素之一。最近的研究表明，这两种疾病之间存在潜在的机制联系。
我们的研究目的是通过检查特定的冠心病危险因素，来描述被转介到预防诊所的 HDL-C 水平极高和极低的患者的特征。
我们通过回顾性病历分析，比较了 HDL-C 水平大于第 90 百分位数的 113 例患者和水平小于第 10 百分位数的 212 例患者的表型。
HDL-C 水平高的队列在 2 型糖尿病的发病率方面存在显著差异（1.8% 比 21.7%）。高 HDL-C 组的年龄也更大（52.1 岁比 46.7 岁），轻或中度饮酒者更多（70.8%比 49.4%），健康饮食者更多（30.1%比 22.4%），轻或中度运动者更多（90.8%比 52.2%），体重指数（BMI）更低（25.2kg/m²比 28.1kg/m²）。
与低 HDL-C 组相比——也与一般人群相比——高 HDL-C 组的糖尿病患病率显著较低。
