胆囊收缩素八肽对人离体消化道肌肉的作用。
The effects of cholecystokinin octapeptide on human isolated alimentary muscle.
作者信息
D'Amato M, Stamford I F, Bennett A
机构信息
Department of Surgery, King's College School of Medicine and Dentistry, Rayne Institute, London.
出版信息
Br J Pharmacol. 1990 May;100(1):126-30. doi: 10.1111/j.1476-5381.1990.tb12063.x.
Abstract
- We studied cholecystokinin octapeptide (CCK-OP) for its motor effects and sites of action on human isolated muscle from stomach, small intestine and colon. 2. CCK-OP induced a concentration-dependent contraction of all the longitudinal muscles and of circular muscle from the stomach and large intestine. The peptide acted directly on these muscles at a site not involving muscarinic receptors. 3. CCK-OP relaxed the circular muscle of the small intestine and/or reduced the contractions to acetylcholine, by stimulating intramural postganglionic inhibitory neurones.
摘要
- 我们研究了胆囊收缩素八肽（CCK-OP）对人胃、小肠和结肠离体肌肉的运动效应及其作用部位。2. CCK-OP可引起胃和大肠所有纵行肌以及环行肌的浓度依赖性收缩。该肽通过作用于不涉及毒蕈碱受体的位点直接作用于这些肌肉。3. CCK-OP通过刺激壁内节后抑制性神经元，使小肠环行肌舒张和/或降低其对乙酰胆碱的收缩反应。
相似文献
1
The effects of cholecystokinin octapeptide on human isolated alimentary muscle.胆囊收缩素八肽对人离体消化道肌肉的作用。
Br J Pharmacol. 1990 May;100(1):126-30. doi: 10.1111/j.1476-5381.1990.tb12063.x.
2
Cholecystokinin stimulates neuronal receptors to produce contraction of the canine colon.胆囊收缩素刺激神经元受体，引起犬结肠收缩。
Life Sci. 1989;44(8):533-42. doi: 10.1016/0024-3205(89)90615-2.
3
Mode of action of cholecystokinin octapeptide on smooth muscles of stomach, ileum and gall bladder.胆囊收缩素八肽对胃、回肠和胆囊平滑肌的作用方式。
Methods Find Exp Clin Pharmacol. 1986 Dec;8(12):697-703.
4
The effects of cholecystokinin-octapeptide and pentagastrin on electrical and motor activities of canine colonic circular muscle.胆囊收缩素八肽和五肽胃泌素对犬结肠环行肌电活动和运动活性的影响。
Can J Physiol Pharmacol. 1984 Dec;62(12):1440-7. doi: 10.1139/y84-239.
5
Dual action of cholecystokinin-octapeptide on the guinea pig antrum.
Gastroenterology. 1987 Feb;92(2):376-82. doi: 10.1016/0016-5085(87)90131-4.
6
Inhibitory action of CCK-OP on rat proximal colon.胆囊收缩素八肽对大鼠近端结肠的抑制作用。
Ann N Y Acad Sci. 1994 Mar 23;713:407-9. doi: 10.1111/j.1749-6632.1994.tb44109.x.
7
Responses of guinea-pig gastric, ileal and gall bladder smooth muscle to desamino-cholecystokinin-octapeptide (CCK 7).豚鼠胃、回肠和胆囊平滑肌对去氨基胆囊收缩素八肽（CCK 7）的反应。
Methods Find Exp Clin Pharmacol. 1988 Aug;10(8):513-20.
8
Actions of cholecystokinin octapeptide on smooth muscle of isolated dog intestine.胆囊收缩素八肽对离体犬肠平滑肌的作用。
Am J Physiol. 1977 Mar;232(3):E306-10. doi: 10.1152/ajpendo.1977.232.3.E306.
9
Cholinergic neurons are involved in the effect of substance P on the circular muscle of the guinea pig small intestine.胆碱能神经元参与了P物质对豚鼠小肠环行肌的作用。
Acta Physiol Hung. 1992;80(1-4):311-6.
10
Effects of cholecystokinin-octapeptide on the human gallbladder both in vivo and in vitro.胆囊收缩素八肽对人体胆囊的体内及体外作用。
Gastroenterol Jpn. 1986 Feb;21(1):49-54. doi: 10.1007/BF02775940.
引用本文的文献
1
Role of CCK/gastrin receptors in gastrointestinal/metabolic diseases and results of human studies using gastrin/CCK receptor agonists/antagonists in these diseases.胆囊收缩素/胃泌素受体在胃肠道/代谢性疾病中的作用以及使用胃泌素/胆囊收缩素受体激动剂/拮抗剂对这些疾病进行人体研究的结果。
Curr Top Med Chem. 2007;7(12):1211-31. doi: 10.2174/156802607780960519.
2
Involvement of endogenous CCK and CCK1 receptors in colonic motor function.内源性胆囊收缩素及胆囊收缩素1受体在结肠运动功能中的作用
Br J Pharmacol. 2004 Apr;141(8):1275-84. doi: 10.1038/sj.bjp.0705769.
3
Studies of three non-peptide cholecystokinin antagonists (devazepide, lorglumide and loxiglumide) in human isolated alimentary muscle and guinea-pig ileum.三种非肽类胆囊收缩素拮抗剂（地伐西匹、洛谷胺和洛昔谷胺）在人离体消化道肌肉和豚鼠回肠中的研究。
Br J Pharmacol. 1991 Feb;102(2):391-5. doi: 10.1111/j.1476-5381.1991.tb12184.x.
本文引用的文献
1
Effect of cholecystokinin and the octapeptide of cholecystokinin on the feline sphincter of Oddi and gallbladder. Mechanisms of action.胆囊收缩素及胆囊收缩素八肽对猫奥迪括约肌和胆囊的作用。作用机制。
J Clin Invest. 1980 Dec;66(6):1231-9. doi: 10.1172/JCI109974.
2
3
Pentagastrin potentiates nonadrenergic inhibitory neuromuscular transmission in orad stomach of the dog.五肽胃泌素增强犬胃贲门部的非肾上腺素能抑制性神经肌肉传递。
Am J Physiol. 1983 Oct;245(4):G597-600. doi: 10.1152/ajpgi.1983.245.4.G597.
4
Inhibition of the action of cholecystokinin octapeptide on the guinea pig ileum myenteric plexus by dibutyryl cyclic guanosine monophosphate.二丁酰环磷酸鸟苷对胆囊收缩素八肽作用于豚鼠回肠肌间神经丛的抑制作用
Brain Res. 1980 Dec 8;202(2):501-5. doi: 10.1016/0006-8993(80)90164-x.
5
Cholecystokinin-octapeptidelike immunoreactivity in human plasma.人血浆中胆囊收缩素八肽样免疫反应性
Gastroenterology. 1982 Mar;82(3):438-44.
6
Evidence that the action of cholecystokinin octapeptide on the guinea pig ileum longitudinal muscle is mediated in part by substance P release from the myenteric plexus.胆囊收缩素八肽对豚鼠回肠纵肌的作用部分是由肌间神经丛释放P物质介导的证据。
Eur J Pharmacol. 1981 Jan 5;69(1):87-93. doi: 10.1016/0014-2999(81)90605-1.
7
Is vasoactive intestinal peptide an inhibitory transmitter in the circular but not the longitudinal muscle of guinea-pig colon?血管活性肠肽是豚鼠结肠环行肌而非纵行肌中的抑制性递质吗？
J Pharm Pharmacol. 1984 Nov;36(11):787-8. doi: 10.1111/j.2042-7158.1984.tb04877.x.
8
A pharmacological study of the motility of the human gastrointestinal tract.人体胃肠道运动的药理学研究。
Gut. 1966 Aug;7(4):307-16. doi: 10.1136/gut.7.4.307.
9
Comparison of effects of gastrin, cholecystokinin-pancreozymin, secretin, and glucagon on human stomach muscle in vitro.胃泌素、缩胆囊素-促胰酶素、促胰液素和胰高血糖素对人胃肌的体外作用比较
Gastroenterology. 1970 Oct;59(4):539-45.
10
Acetylcholine-releasing effect of gastrin and related polypeptides.胃泌素及相关多肽的乙酰胆碱释放作用。
Eur J Pharmacol. 1972 Jan;17(1):175-8. doi: 10.1016/0014-2999(72)90286-5.
Zotero 插件