Alzheimer Centre Limburg, School for Mental Health and Neuroscience, University Medical Centre, Maastricht, The Netherlands.
Alzheimer Centre Limburg, School for Mental Health and Neuroscience, University Medical Centre, Maastricht, The Netherlands.
Alzheimers Dement. 2014 Mar;10(2):225-37. doi: 10.1016/j.jalz.2013.02.005. Epub 2013 May 30.
The objective of this study is to systematically review the literature on economic evaluations of interventions for the early diagnosis of Alzheimer's disease (AD) and related disorders and to describe their general and methodological characteristics. We focused on the diagnostic aspects of the decision models to assess the applicability of existing decision models for the evaluation of the recently revised diagnostic research criteria for AD.
PubMed and the National Institute for Health Research Economic Evaluation database were searched for English-language publications related to economic evaluations on diagnostic technologies. Trial-based economic evaluations were assessed using the Consensus on Health Economic Criteria list. Modeling studies were assessed using the framework for quality assessment of decision-analytic models.
The search retrieved 2109 items, from which eight decision-analytic modeling studies and one trial-based economic evaluation met all eligibility criteria.
Diversity among the study objective and characteristics was considerable and, despite considerable methodological quality, several flaws were indicated. Recommendations were focused on diagnostic aspects and the applicability of existing models for the evaluation of recently revised diagnostic research criteria for AD.
本研究旨在系统综述有关阿尔茨海默病（AD）及相关疾病早期诊断干预措施的经济学评价文献，并描述其一般特征和方法学特征。我们重点关注决策模型的诊断方面，以评估现有决策模型在评估最近修订的 AD 诊断研究标准中的适用性。
检索了 PubMed 和英国国家卫生研究院经济评价数据库中有关诊断技术经济学评价的英文文献。采用共识健康经济标准清单评估基于试验的经济学评价，采用决策分析模型质量评估框架评估建模研究。
检索到 2109 项研究，其中 8 项决策分析模型研究和 1 项基于试验的经济学评价符合所有纳入标准。
研究目的和特征的多样性非常大，尽管方法学质量较高，但也存在一些缺陷。建议侧重于诊断方面以及现有模型在评估最近修订的 AD 诊断研究标准中的适用性。
