Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Environmental Health Center, Seoul National University College of Medicine, Seoul, Korea.
J Prev Med Public Health. 2021 Nov;54(6):395-403. doi: 10.3961/jpmph.21.384. Epub 2021 Oct 22.
Previous studies have shown that participation in social activities (SA) can prevent cognitive decline (CD) and that living arrangements (LA) can affect cognitive function. This study aimed to evaluate the effects of SA and LA on CD, as well as their interactions, using longitudinal data.
Data were used from the 2006-2018 Korean Longitudinal Study for Aging, which followed 10 254 adults older than 45 years over a 12-year period. CD was defined as a ≥4-point score decrease in the Mini-Mental Status Exam over 2 years. We developed an extended Cox proportional hazards model for time-dependent covariates to estimate the hazard ratio (HR) of CD in 4 groups: (1) socially active and living with others, (2) socially active and living alone, (3) socially inactive and living with others (SILO), and (4) socially inactive and living alone (SILA). The model was stratified by gender and adjusted for important confounders.
The HR of CD was significantly higher in the SILO group in men (HR,1.36; 95% confidence interval [CI], 1.08 to 1.78) and in the SILA group in women (HR, 1.72; 95% CI, 1.08 to 2.75). However, the interaction term for gender was not significant.
Among socially inactive elderly adults, the HR of CD was elevated in men who lived with others and in women who lived alone, although the interaction term for gender was not significant. Socially inactive men who live with others and socially inactive women who live alone are particularly encouraged to participate in SA to prevent CD.
先前的研究表明,参与社会活动(SA)可以预防认知能力下降(CD),而居住安排(LA)可以影响认知功能。本研究旨在使用纵向数据评估 SA 和 LA 对 CD 的影响及其相互作用。
本研究使用了来自 2006-2018 年韩国老龄化纵向研究的数据,该研究在 12 年内跟踪了 10254 名 45 岁以上的成年人。CD 定义为在 2 年内 Mini-Mental 状态检查得分下降≥4 分。我们开发了一个扩展的 Cox 比例风险模型来估计 4 组的 CD 风险比(HR):(1)社交活跃且与他人同住,(2)社交活跃且独居,(3)社交不活跃且与他人同住(SILO),(4)社交不活跃且独居(SILA)。该模型按性别分层,并调整了重要混杂因素。
男性 SILO 组和女性 SILA 组的 CD 风险比(HR)显著升高(HR,1.36;95%置信区间[CI],1.08 至 1.78;HR,1.72;95%CI,1.08 至 2.75)。然而,性别交互项不显著。
在社交不活跃的老年人群中,与他人同住的男性和独居的女性 CD 风险比(HR)升高,尽管性别交互项不显著。鼓励与他人同住的社交不活跃的男性和独居的社交不活跃的女性积极参与 SA 以预防 CD。