Department of Tumor Research and Therapy Center, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
Taian Central Hospital, Taian, Shandong 271000, China.
Life Sci. 2013 Jul 19;93(1):1-6. doi: 10.1016/j.lfs.2013.05.016. Epub 2013 May 30.
Caveolae, plasma membrane invaginations of 60-80nm in diameter, are a subset of lipid rafts enriched in cholesterol and sphingolipids. Caveolae are expressed in various tissues and cell types, such as endothelial cells, macrophages, neutrophils and adipocytes. The functions of caveolae are diverse and include endocytosis, transcytosis, potocytosis, calcium signaling, and regulation of various signaling events. Although growing evidence has increased our understanding of caveolae function, the role of caveolae in sepsis is still a controversial issue. In this review, we present a number of studies addressing caveolae and sepsis and describe the signaling pathways involved, including the LPS-eNOS-TLR4-NFκB, MKK3/p38 MAPK, cPLA2/p38 MAPK, STAT3/NFκB and IL-1β-IL-1R1 pathways. Different studies using endotoxemia and bacteremia animal models have provided distinct conclusions about the function of caveolae, and we discuss these inconsistencies. Taken together, the current data suggest that the function of caveolae in sepsis, which involves a number of signaling pathways, is complex and warrants further studies.
小窝，直径 60-80nm 的质膜内陷，是富含胆固醇和鞘脂的脂筏的一个子集。小窝在各种组织和细胞类型中表达，如内皮细胞、巨噬细胞、中性粒细胞和脂肪细胞。小窝的功能多种多样，包括内吞作用、转胞吞作用、胞饮作用、钙信号转导以及各种信号事件的调节。尽管越来越多的证据增加了我们对小窝功能的理解，但小窝在脓毒症中的作用仍然是一个有争议的问题。在这篇综述中，我们提出了一些关于小窝和脓毒症的研究，并描述了所涉及的信号通路，包括 LPS-eNOS-TLR4-NFκB、MKK3/p38 MAPK、cPLA2/p38 MAPK、STAT3/NFκB 和 IL-1β-IL-1R1 通路。使用内毒素血症和菌血症动物模型的不同研究对小窝的功能得出了不同的结论，我们讨论了这些不一致之处。总之，目前的数据表明，小窝在脓毒症中的功能涉及许多信号通路，是复杂的，需要进一步研究。
