Barts Cancer Institute, John Vane Science Centre, London, United Kingdom.
J Clin Invest. 2013 Jun;123(6):2355-7. doi: 10.1172/JCI69999.
Failing immunity has been acknowledged for its contribution to cancer development and progression. Recent clinical findings have provided payoffs for significant preclinical evaluation and refinement over the last 20 years, but many questions remain to be answered. In this issue of the JCI, Marabelle et al. describe a novel method for targeting the Tregs that infiltrate tumors, demonstrating that dampening the tumor immunosuppressive environment while activating innate antitumor immunity may be an effective approach to cancer treatment.
免疫失效已被认为是癌症发展和进展的原因之一。最近的临床发现为过去 20 年的大量临床前评估和改进提供了回报，但仍有许多问题有待解答。在本期 JCI 中，Marabelle 等人描述了一种针对浸润肿瘤的 Tregs 的新方法，证明抑制肿瘤免疫抑制环境同时激活先天抗肿瘤免疫可能是一种有效的癌症治疗方法。
