Department of Cardiovascular Pulmonary Research, University of Colorado Denver, Aurora, Colorado, USA.
Compr Physiol. 2012 Jan;2(1):295-319. doi: 10.1002/cphy.c100070.
he relationship between cardiac function and the afterload against which the heart muscle must work to circulate blood throughout the pulmonary circulation is defined by a complex interaction between many coupled system parameters. These parameters range broadly and incorporate system effects originating primarily from three distinct locations: input power from the heart, hydraulic impedance from the large conduit pulmonary arteries, and hydraulic resistance from the more distal microcirculation. These organ systems are not independent, but rather, form a coupled system in which a change to any individual parameter affects all other system parameters. The result is a highly nonlinear system which requires not only detailed study of each specific component and the effect of disease on their specific function, but also requires study of the interconnected relationship between the microcirculation, the conduit arteries, and the heart in response to age and disease. Here, we investigate systems-level changes associated with pulmonary hypertensive disease progression in an effort to better understand this coupled relationship.
心脏功能与心肌在整个肺循环中循环血液时必须克服的后负荷之间的关系是由许多耦合系统参数之间的复杂相互作用定义的。这些参数范围很广，主要包含三个不同位置的系统效应：来自心脏的输入功率、大导管肺动脉的液压阻抗以及更远端微循环的液压阻力。这些器官系统不是独立的，而是形成一个耦合系统，其中任何一个参数的变化都会影响所有其他系统参数。其结果是一个高度非线性系统，不仅需要详细研究每个特定组件以及疾病对其特定功能的影响，还需要研究微循环、导管动脉和心脏之间的相互关联关系，以应对年龄和疾病的影响。在这里，我们研究与肺动脉高压疾病进展相关的系统级变化，以更好地理解这种耦合关系。
